ID A0A0A6UNG7_ACTUT Unreviewed; 1695 AA.
AC A0A0A6UNG7;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KHD76966.1};
GN ORFNames=MB27_14350 {ECO:0000313|EMBL:KHD76966.1};
OS Actinoplanes utahensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1869 {ECO:0000313|EMBL:KHD76966.1, ECO:0000313|Proteomes:UP000054537};
RN [1] {ECO:0000313|EMBL:KHD76966.1, ECO:0000313|Proteomes:UP000054537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 12052 {ECO:0000313|EMBL:KHD76966.1,
RC ECO:0000313|Proteomes:UP000054537};
RA Velasco-Bucheli B., del Cerro C., Hormigo D., Garcia J.L., Acebal C.,
RA Arroyo M., de la Mata I.;
RT "Draft genome sequence of Actinoplanes utahensis NRRL 12052.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHD76966.1}.
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DR EMBL; JRTT01000014; KHD76966.1; -; Genomic_DNA.
DR RefSeq; WP_043524928.1; NZ_JRTT01000014.1.
DR STRING; 1869.MB27_14350; -.
DR eggNOG; COG0515; Bacteria.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG3706; Bacteria.
DR eggNOG; COG3899; Bacteria.
DR OrthoDB; 5521237at2; -.
DR Proteomes; UP000054537; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00065; GAF; 2.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000054537}.
FT DOMAIN 4..264
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1559..1687
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT BINDING 32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1695 AA; 178108 MW; 0D4CC55805E3D8F0 CRC64;
MPGLRGWTEI GRGAHSVVYR AVRPDGAEVA VKVLPDGAAR TPLYREAAWT AICRHPGLPE
VYDAGEVDGR PYLVMELVTG NRLGDLLRAG RLTPARVALI GADIAEALTA VHRAGLVHRD
VKPDNVMVGA DGRARLVDLG MAARSGELCG DEIAGTLTYT APEQNGSLRR PVDARSDLYS
LGVVLYECLA GRPPFRAADT GELMRLHAVA APPALPAPEG NRAEGPLAAV VARLLAKDPD
DRYAGAPGLA ADLRSVAAAP DAALTVGAAD RPVTPAEPPL AGRERELGEL AGCWARIRDG
ARVAVIRGEA GLGRSRLLRE FAGRLHGAGV TVLRGAGRPG DPPLAVLSQM VDALAARAEP
DLLRAAAGAA APYLGRLSPV LRKVVNVAPV LSEDSGAYPR AVAAFLAGLA RQSGGAVLAI
DDAHWLDDTT AQVLRQVLTQ HATAPLLILV TTDTGVPVVW GGEDAAGIVL EPLDDTAARQ
QFAAICGGYP VAAGLPERFA ARAGGRPLTL SVLLRGAIDA GVLVPRDGRL HIDSERLQHL
QIPDDLEGLL LSRIDGLGAA GREMLTAAAI VGLRFDAGTA ALVAGRDEAE ARDCFGTAAG
RGILEDGDGG YWFVHERVHR ALLGALTPER RRDLHQRAAE VTAGEAADAR ARYATARHRL
AGHPGRAPRR TVSACLAAAR SALGEHAALD AIGFLEAARP YADGADPVTA DALTETLGRA
YAQAGRLVEA EEQFRAALGA TADPMRRAGL HEQLAQLHLG RWQIDRSLRE VELGLAALGA
DPARGPVRRV VSGLGYLLGA VLVERTRIGF GTADPDRLAR RRQLFALYAA GSYAALLSTR
LPLMADHELR ARYAAARIGP SEEYIRQVGH NAALQQSVTR RPAKRSFARA GRVAAELGSP
AGAAYVEYLR RLTETQTGDP DLDEYLHWLR RHSALLTPSD NLNLALAVSA RHDLRGRRAR
THAAVEQAFG YLGAPDLQHG AVSRLYGAGG TVDLDDAAAL LDEPDAALGG GAGRLMPLVT
IITAAYHQHE FGDVFDRATT AFRALRIRPL ALAATLRTVY VAIAYGRLEQ LRGAGPEQRA
AATAEAGRAV RDLRDASIGG RGACRELAAH HALVTAMLAW DTAGSERARR RARDLLVKAE
RRAGDHDVPA VTAGTMLMRA RIAAYAGRAE EAAAHAGAAV RLAGDLGMLE FAYVVRREFG
VGGDVVRRSA TEDGTADRRR LAALERLSRT VSGMIALDAL SRAVLDETVL ILNAERAYLF
LADDDDRLLP FSGRDAHGAD LAILTDYGST IVERVWRTGE PVVVTGTDEG AALGSASVVL
HGLRSIMAAP LVLDGRMLGV VYLDSRVAKG MFTGADVGIL SAITQHVAAA VETARAAQLA
VAVRAAEQQR DMADMLRESL IRFSRSLDPA AVLAELHAAL ARVLPADGSW LVRASEDGDL
ALIGAGGGPL ERSATLNALL AAPGPVAVTA DLGFSAGAHL AVPLHRQGTP VGLVLLTGGS
YGPTEITLAA ALAEEAMVVY DNAALFARVE YLATTDALTG VSNRRHFFTL AEAMAVASGG
FTAVMADIDH FKKINDRYGH QVGDQVITAV AARLRDASPP GGQVGRYGGE EFAAVWPGLD
DPAGLAERLR RAVTDRPVET DAGPLTVTVS VGVCPATTGL DAALRAADAA LYRAKRDGRD
RVACARPAEV ACSPV
//
