ID A0A0A7I859_9BIFI Unreviewed; 805 AA.
AC A0A0A7I859;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=CRISPR-associated protein Cas3 {ECO:0000313|EMBL:AIZ14979.1};
GN ORFNames=AH68_07825 {ECO:0000313|EMBL:AIZ14979.1};
OS Bifidobacterium catenulatum PV20-2.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=1447716 {ECO:0000313|EMBL:AIZ14979.1, ECO:0000313|Proteomes:UP000030625};
RN [1] {ECO:0000313|EMBL:AIZ14979.1, ECO:0000313|Proteomes:UP000030625}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PV20-2 {ECO:0000313|EMBL:AIZ14979.1,
RC ECO:0000313|Proteomes:UP000030625};
RX PubMed=25614572;
RA Vazquez-Gutierrez P., Lacroix C., Chassard C., Klumpp J., Jans C.,
RA Stevens M.J.;
RT "Complete and Assembled Genome Sequence of Bifidobacterium kashiwanohense
RT PV20-2, Isolated from the Feces of an Anemic Kenyan Infant.";
RL Genome Announc. 3:0-0(2015).
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; CP007456; AIZ14979.1; -; Genomic_DNA.
DR RefSeq; WP_039199059.1; NZ_CP007456.1.
DR AlphaFoldDB; A0A0A7I859; -.
DR STRING; 1447716.AH68_07825; -.
DR KEGG; bka:AH68_07825; -.
DR HOGENOM; CLU_010123_0_0_11; -.
DR OrthoDB; 9810236at2; -.
DR Proteomes; UP000030625; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF16; CRISPR-ASSOCIATED NUCLEASE_HELICASE CAS3-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 9..197
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 259..446
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 328..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 805 AA; 90845 MW; 4E2D98E5E2946EE8 CRC64;
MDLLAHRDAD GNVQTLHGHL HGAGDLAESY ESEFSQISRM AALLHDVGKV AQQFQTYLIS
GKGRRGEIPH ARQGAFVVND LPISNSAAEI VKEILELVIA KHHGELPDCI NEIGDEAFLT
GFTEADKQNP KYAYGEIKQG LHDLDLDLQD TFQQAEKDVF DFAGRTKSLK LSKDSRYFYS
GLLVKYVYSR LIDADRTDTA YFETKEQYHP IKADWSELIR HLDESMKSFD STSEINKIRQ
QITEQCRQAG SRETGIYRLS VPTGGGKTLA SLNFALHHAL ETGKRRIIYV IPYLSITSQT
VATFRNMLGL DADSNIVLEH YSTAGLQNSD NTGSIGTSEE EDAKERQRKL ASERWDNPII
VTTMVEFLET VMSARGTKLR KFHNMANSVI IFDEIQSLPL NIINPFNEVV SFLSTILDST
ILLCSATQPL LERTARKNLR LSDEPDLIDN TDGYEEKLKR TRIIASQESK SCEELANIIY
EQALRNGNCL SIVNTKSEAR KMYQCLQELN ADGQFELIHL STAMCGKHRA DQLARIKVLT
DPHDSKPVIC VSTQLIEAGV DLSFACVVRA MAGLDSIMQA AGRCNRNGES KEIKDVYVYP
LQGEERFKDY LPEIHRGKKL TLQIMGEHPD ADLLSTGMLN EFYGMLLQSE DRDGGNSLLD
GSLWKKENAG KTIYELLAYN ESQRKQFENN TMGERYNPFF AQAFKTVGNE YRVIPKITHN
VVVPYGNAME LLDMLGHGEL REKIAILRRL QEYTVSLFDY EYKILNEKHA ISIANEDFDI
CVLNGDYYKG EYGVVTETDM SLLMI
//
