ID   A0A0A8L053_9SACH        Unreviewed;      1226 AA.
AC   A0A0A8L053;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=WGS project CCBQ000000000 data, contig 00041 {ECO:0000313|EMBL:CDO92400.1};
GN   ORFNames=KLDO_g720 {ECO:0000313|EMBL:CDO92400.1};
OS   Kluyveromyces dobzhanskii CBS 2104.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=1427455 {ECO:0000313|EMBL:CDO92400.1, ECO:0000313|Proteomes:UP000031516};
RN   [1] {ECO:0000313|EMBL:CDO92400.1, ECO:0000313|Proteomes:UP000031516}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS2104 {ECO:0000313|Proteomes:UP000031516};
RA   Nystedt B., Astrom S.;
RT   "The genome of Kluyveromyces dobzhanskii.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDO92400.1}.
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DR   EMBL; CCBQ010000013; CDO92400.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A8L053; -.
DR   OrthoDB; 5100844at2759; -.
DR   Proteomes; UP000031516; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04435; DEP_fRom2; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041675; PH_5.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF15405; PH_5; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00036; CNH; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
FT   DOMAIN          540..727
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          916..1205
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          115..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1226 AA;  138502 MW;  634550917A3C506A CRC64;
     MSYSSSDLEH GSRRQLLTQI FGIERPLSPS PSGVPRELPD SLDMISLKAV LNEDVENDLV
     QNRTQVVPNE NGFEGGLFKS PVHVRQVSDV GSSDIEDDGM TSPEATSPQA YLSQDLSMPK
     QRPASHHNHG RPAPPTMGMI HESPRRSKSE NFNLKPSLPK LSTTNNATSN GGSYNNNISN
     PNSRGSFIAK KSPLQGFGLF SRSTSKDLQA ESNLSPTGNH NYASSDHIFG RTQSISSSTF
     KNFTSSLHGK NKTVGGRTIP QKYDFSTNPL LDSSSGLGLK QRASSASLSN DSAISRHIRR
     TSTSSLHTKH IVVSSSIRRP QVYPAMLSRV ATAFKKSIAL GEYKKDGLFY RDAFTGHQAI
     DVICSIIRTN DRNLALLLGR ALDAQKLFHD VIYEHRLRDS PNEVYEFTGN SRVIGKGIYE
     IDSPNDFSAS QSTTNIVPSQ SESSLSLMAK PEDPDSFHQV NGVFTLLAEC YSPTCTRNRL
     CYSISCPKRL EQQARLNLKP NGGLKRNMSM AIDDDDEEKS SWTSSVPEEL WSSLSKREIK
     RQEAIYEVYS TEKKFVKSLE ILRDTFMKKL AETNIIPADI RKNFIKHVFA HVNDIFSVNR
     RLLDALTERQ KASPIVEGIG DILLRFVPFF EPFVMYVASR PYAKYLIETQ RSVNPYFARF
     DDDLMNSVLR HGIDSFLSQG VSRPGRYVLL VREIMKSTDP EREKRDLENL TRALEALRAF
     MKRIDKASGA AQDRHDVKLL KQKILFKNEY VNMGLNDDTR KIKHEGLLSR KEITKNENGV
     TGDIQFYLLD NMLLFLKSKA VNKWNQHKVF QRPIPLPLLF AAPGEEMPNL KKYISGKPDS
     QGTVVYPEVA VGTNPRNAIS ISYYGAKHKY QVTLFAAQYA AMQTLLEKIK QEQARIIKEN
     DIFNICKISD RFFDYSNKIN SVASCDGGRK LIIATSQGLF VSNIRRAENS IIFDAPTKLL
     SKNNVSQLSV LEEFQSILIL VDKKLYSCSF DILKITDCQM GNSHFKKHAK ELVTHVSFFS
     DGDCNGKKLI VTAHSSHNSI KYFEHEHPLL QEKKHPKKKF TEVQFDSEPV SISFLKANLC
     IGCKKGFQIV SVSQNAHEPL LDPADTSLDF ALKDSLHPQV IYRVGNMFFL CYTEFAFFVN
     NQGWRKKEYH VVHWEGEPEK FAIWYPYIIA FDSNFIEVRK VETGELVRCV VGEKIRLLQT
     SSQEILYAYE DERGYDTIAS LDFWGK
//