ID A0A0A8L4W6_9SACH Unreviewed; 603 AA.
AC A0A0A8L4W6;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 22-FEB-2023, entry version 35.
DE RecName: Full=Pescadillo homolog {ECO:0000256|HAMAP-Rule:MF_03028};
DE AltName: Full=Nucleolar protein 7 homolog {ECO:0000256|HAMAP-Rule:MF_03028};
GN Name=NOP7 {ECO:0000256|HAMAP-Rule:MF_03028};
GN ORFNames=KLDO_g2230 {ECO:0000313|EMBL:CDO93942.1};
OS Kluyveromyces dobzhanskii CBS 2104.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=1427455 {ECO:0000313|EMBL:CDO93942.1, ECO:0000313|Proteomes:UP000031516};
RN [1] {ECO:0000313|EMBL:CDO93942.1, ECO:0000313|Proteomes:UP000031516}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS2104 {ECO:0000313|Proteomes:UP000031516};
RA Nystedt B., Astrom S.;
RT "The genome of Kluyveromyces dobzhanskii.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. Within the NOP7 complex ERB1 appears to interact directly with
CC NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-
CC ribosome. {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000256|HAMAP-
CC Rule:MF_03028}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDO93942.1}.
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DR EMBL; CCBQ010000027; CDO93942.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A8L4W6; -.
DR OrthoDB; 169151at2759; -.
DR Proteomes; UP000031516; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR CDD; cd17709; BRCT_pescadillo_like; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PESCADILLO - RELATED; 1.
DR PANTHER; PTHR12221:SF6; PESCADILLO HOMOLOG; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|HAMAP-Rule:MF_03028};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517, ECO:0000256|HAMAP-
KW Rule:MF_03028};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552, ECO:0000256|HAMAP-
KW Rule:MF_03028}.
FT DOMAIN 346..440
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 300..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..508
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 603 AA; 69231 MW; C370886F441B83D8 CRC64;
MRIKKRNTRG NARNFITRSQ AVRKLQISLA DFRRLCIFKG IYPREPRNKK KANKGSTAPT
TFYYYKDIQY LMHEPVLAKF REHKTFSKKL TKALGRGEVS AAKRLEENRP NYELDHIIKE
RYPSFADALR DVDDALNMLF LFANLPATDQ VSSRITQSAQ QLCNQWAAYI AKERCVRKVF
VSIKGVYYQA SVKGEDVRWL VPYKFPENIP SDVDFRIMLT FLEFYSTLLH FVLFRLYVDS
GLVYPPKLDT KKNKLIGGLS AYILESNDEK SSLALHPKEI SEDAAVQELG AKALKTALNA
DSKKHDEEEE DQEDQEDVED VELDRFEDNN KNQGDLLEQP SKFDSPTATL FSDFVFYVGR
EVPLDIVEFL ILSCGGSVVS EATLDQIADK KDIDLSKVTH QIVDRPVLKN KVANRTYIQP
QWIFDSINKV ELVPANLYLP GEPLPPHLSP WGDATGYDPT AEDDQEDEDS EEEDVDESAD
EAVDIDEESA EAIALNEDDD EDEDELRQQK ELELEAQGVS YSEGKDTIQG EGSEKKAKKN
KRKATEEEEE KDLKLIMMSN KQRKLYKKMK YSNEKKDEKI EQLKQKKKQI AKTKSKLAKL
DKK
//
