ID   A0A0A8L778_9SACH        Unreviewed;       759 AA.
AC   A0A0A8L778;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=WGS project CCBQ000000000 data, contig 00102 {ECO:0000313|EMBL:CDO93991.1};
GN   ORFNames=KLDO_g2277 {ECO:0000313|EMBL:CDO93991.1};
OS   Kluyveromyces dobzhanskii CBS 2104.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=1427455 {ECO:0000313|EMBL:CDO93991.1, ECO:0000313|Proteomes:UP000031516};
RN   [1] {ECO:0000313|EMBL:CDO93991.1, ECO:0000313|Proteomes:UP000031516}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS2104 {ECO:0000313|Proteomes:UP000031516};
RA   Nystedt B., Astrom S.;
RT   "The genome of Kluyveromyces dobzhanskii.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC       {ECO:0000256|ARBA:ARBA00005634}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDO93991.1}.
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DR   EMBL; CCBQ010000027; CDO93991.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A8L778; -.
DR   OrthoDB; 67337at2759; -.
DR   Proteomes; UP000031516; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd08022; M28_PSMA_like; 1.
DR   CDD; cd02121; PA_GCPII_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR039373; Peptidase_M28B.
DR   InterPro; IPR007365; TFR-like_dimer_dom.
DR   InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR   PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR   PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   Pfam; PF04253; TFR_dimer; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        36..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          181..247
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          371..559
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
FT   DOMAIN          639..755
FT                   /note="Transferrin receptor-like dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF04253"
FT   REGION          247..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   759 AA;  85077 MW;  758D387B69E4BFA1 CRC64;
     MTFRNVKEYR ADIKHDLNDI EAQKTSSSKK TLTKKLLLIA FQVCVLCFAG NTVLNYSFSS
     ETLRDRSKAT PTELAYLQIL DDTNYAGKWS EKLTSVPHLA GQGIELVDWT ASKFEEYGLT
     TEVEAFDIYL NYPVGNGLTL LSNGEPIYQA NLTEDVLPED STTGGDDVVP AFHGYSASGN
     VTAEYVYVNY GSKEDFDLLE EFGVSLKGRI AIARYGKIFR GLKVKFAQEA GAAGVLIYSD
     PGDDFFQEAK GDKPYPNGPA RNPSSLQRGS VQFLSQFPGD PTTPGRPSQG DDVVRDDPYK
     SIPKIPSLPV SFKEVKPILE KLNGHGLKGS TIGGDKWVGN LLGFDYWTGP NPKNTINLYN
     EQKYDIVPIH NVYGTLEGYD PKSGYILVGN HRDAWIKGGA SDPNSGTAAM LEIMRSLHNL
     TQTGWKPRRT IKFASWDGEE YALLGSTEFG EKNGEELKKN LLAYLNVDVA VSGRKLQISS
     SPFLNNAIKE TLPLIDYPLQ ENLTLEEHFF NHSKINILGS GSDYTVFLEH LGIASLDVGF
     GATAEDPVYH YHSNYDSFHW MSTMQDPGFK LHNTIAKLLG TLTLRLSEDK IINTKVSDYS
     IELAKYYHAI EANVPQQWLN ITNHRGKPLI DLIHKTNVKL DQLATSGSAF DDYLTDLNKQ
     WDGVDSLPWW NRIKLHFKIV GANFKLFYLE RVFLHEEGLK DRPWFKHIIF ASGKYTGYEG
     FALPGLKEAL DDTNIKDFVH WNKIFLHTIK GLVDSFDRK
//