ID A0A0B0H327_SOVGS Unreviewed; 290 AA.
AC A0A0B0H327;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:OOY34079.1};
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase-like protein {ECO:0000313|EMBL:KHF24618.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:KHF24618.1};
GN ORFNames=BOV88_12050 {ECO:0000313|EMBL:OOY34079.1}, JV46_09620
GN {ECO:0000313|EMBL:KHF24618.1};
OS Solemya velum gill symbiont.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; sulfur-oxidizing symbionts.
OX NCBI_TaxID=2340 {ECO:0000313|EMBL:KHF24618.1, ECO:0000313|Proteomes:UP000030856};
RN [1] {ECO:0000313|EMBL:KHF24618.1, ECO:0000313|Proteomes:UP000030856}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH {ECO:0000313|EMBL:KHF24618.1,
RC ECO:0000313|Proteomes:UP000030856};
RX PubMed=25342549; DOI=10.1186/1471-2164-15-924;
RA Dmytrenko O., Russell S.L., Loo W.T., Fontanez K.M., Liao L., Roeselers G.,
RA Sharma R., Stewart F.J., Newton I.L., Woyke T., Wu D., Lang J.M.,
RA Eisen J.A., Cavanaugh C.M.;
RT "The genome of the intracellular bacterium of the coastal bivalve, Solemya
RT velum: a blueprint for thriving in and out of symbiosis.";
RL BMC Genomics 15:924-924(2014).
RN [2] {ECO:0000313|EMBL:OOY34079.1, ECO:0000313|Proteomes:UP000190962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MA-KB16 {ECO:0000313|EMBL:OOY34079.1};
RA Russell S.L., Corbett-Detig R.B., Cavanaugh C.M.;
RT "Mixed transmission modes and dynamic genome evolution in an obligate
RT animal-bacterial symbiosis.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHF24618.1}.
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DR EMBL; JRAA01000002; KHF24618.1; -; Genomic_DNA.
DR EMBL; MPNX01000023; OOY34079.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B0H327; -.
DR STRING; 2340.JV46_09620; -.
DR PATRIC; fig|2340.3.peg.1262; -.
DR eggNOG; COG2084; Bacteria.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000030856; Unassembled WGS sequence.
DR Proteomes; UP000190962; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KHF24618.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030856}.
FT DOMAIN 2..161
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 164..283
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 290 AA; 30303 MW; 59BE39F758B18536 CRC64;
MKVGYIGLGL MGRPCAMHLH NAGHQLAVYA RRETSAAPFA EIGATICATP AEVAVNADVI
FTNVSDTPDV EQIILGKDGI IEGIKPDAVV VDMSTISPVV TRDIAQKLKE KGAHMLDAPV
SGGSAGAESG TLSIMIGGEE AIVERIMPLF EVMGSNIVHI GDNGAGQVTK ACNQIVITQT
IAGVAEAYCL ADAMDVDKAK VRQALLGGFA NSKILEMHGQ RMLDDNYDPG FKAVLHKKDM
NMVLQAASAL GVALPGSGVA TQWLNALVGD GSGELDSSAI YKVMKKFNQA
//
