ID A0A0B0PMF5_GOSAR Unreviewed; 516 AA.
AC A0A0B0PMF5;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Secologanin synthase {ECO:0000313|EMBL:KHG26170.1};
GN ORFNames=F383_32316 {ECO:0000313|EMBL:KHG26170.1};
OS Gossypium arboreum (Tree cotton) (Gossypium nanking).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29729 {ECO:0000313|EMBL:KHG26170.1, ECO:0000313|Proteomes:UP000032142};
RN [1] {ECO:0000313|Proteomes:UP000032142}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. AKA8401 {ECO:0000313|Proteomes:UP000032142};
RA Mudge J., Ramaraj T., Lindquist I.E., Bharti A.K., Sundararajan A.,
RA Cameron C.T., Woodward J.E., May G.D., Brubaker C., Broadhvest J.,
RA Wilkins T.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; KN435314; KHG26170.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B0PMF5; -.
DR Proteomes; UP000032142; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR PANTHER; PTHR24282:SF226; CYTOCHROME P450 CYP749A22-LIKE ISOFORM X1; 1.
DR PANTHER; PTHR24282; CYTOCHROME P450 FAMILY MEMBER; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000032142};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 516 AA; 58346 MW; 877690307842CBD5 CRC64;
MSGLMKFVIL VPCSFFLLAL IKFLYDYLWI PLRIQHMLNS QGIKGPRYKF IHGNNDEATQ
MTKEALSKPM ALTHDIFPRV QPHIYSCINR YGRNFLYWDG VRPELVISEP ELIKEVLKNS
EKTFPKRKPT IFINKLLGDG LVTVEGEKWV KQRKLANNVF HGESLKDMRP AIIASVETML
KKWKGQVGKE IEVFHEFKLL TSEVISRTAF GSSYLEGEKI FEMLNKLSIV LSRNLSNTRI
PLFVKLQKPA DMLEAEELAK GIQDCVSKIV KTREDKVVKG EADNFGIDFL GLLINAYHDT
DENNKLSLED LVNECKTFYF AGQDTVNSLL AWMVLLLASQ GDWQEKARRE VIEIFGNQYP
NSEGLSKLKI MTMIINESLR LYGPAVGLLR KGGTEVRLGN LVLPADIDIL IANAALHHDP
QLWGDNVHLF KPERFAEGIA KATNYNTTAF CPFGLGPRTC VGTTFAIMEV KIAVSMILQR
YTISLSPAYV HAPVSIITVK PQHGIQVILE SLHHDA
//
