ID A0A0B1PGR4_UNCNE Unreviewed; 1199 AA.
AC A0A0B1PGR4;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=EV44_g6105 {ECO:0000313|EMBL:KHJ36046.1};
OS Uncinula necator (Grape powdery mildew).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Erysiphe.
OX NCBI_TaxID=52586 {ECO:0000313|EMBL:KHJ36046.1, ECO:0000313|Proteomes:UP000030854};
RN [1] {ECO:0000313|EMBL:KHJ36046.1, ECO:0000313|Proteomes:UP000030854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=c {ECO:0000313|Proteomes:UP000030854};
RX PubMed=25487071;
RA Jones L., Riaz S., Morales-Cruz A., Amrine K.C., McGuire B., Gubler W.D.,
RA Walker M.A., Cantu D.;
RT "Adaptive genomic structural variation in the grape powdery mildew
RT pathogen, Erysiphe necator.";
RL BMC Genomics 15:1081-1081(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHJ36046.1}.
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DR EMBL; JNVN01000162; KHJ36046.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B1PGR4; -.
DR STRING; 52586.A0A0B1PGR4; -.
DR HOGENOM; CLU_001832_0_4_1; -.
DR OMA; EAIHNNS; -.
DR OrthoDB; 5490433at2759; -.
DR Proteomes; UP000030854; Unassembled WGS sequence.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:KHJ36046.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030854}.
FT DOMAIN 377..554
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 576..815
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 216..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1199 AA; 135286 MW; BB6AF7525D84F9E5 CRC64;
MPPKFIPRQR KHKVLSRHKL TDGNIELKSD SNISEILPSS KTEIQEKKRL IKENLRKNGI
KVNSKKAKRL EKYLETKLRK DENRQLISLL AESKSDTSLY YSSSRLGQGK LARNQGFETA
VRNNDAGVSI DSNENQFNSD ENTVTNDDLR ISPCEDNIDE TSKASVLTTQ KQTDITVGAG
LKKPLEISKE GIPILGKRKR RGGIVSKFSL DIRKPVTDDE SEWEGINSDS SMSIQRDTIG
NMTNSSEDVG DKIGPNLSDY ESDSSKESSR DENESSDDCD EIENTPRKER SAFKAWAIQQ
INEAQGYKSI PNIQMVKTLP NNLTIKLRAP EEDPLPSELR PTENSTRKSH SVAVTRPPEI
EKMRIELPIV AEEQKIMESV FNNNTVVICG ATGSGKTTQV PQFLFEAGYA SSESSTPGII
GITQPRRVAA VSMAKRLGDE LGDLQKKVAY QIRFEATVSP ETAIKFMTDG VLLREIAQDI
TLRKYSAIII DEAHERSVNT DILIGMLSRV VKLREEMSVE NPSIYPLKFI IMSATIRIKD
FIENKNLFTS PPPVIEVEGR QYPVTCHFSR RTSYNYVDEA FKKISRGHKK LPPGSFLVFL
TSQNEIFQLS KLLNEAFRTG TSIIDPKVKI SGKDAPIETE DIEFGDFMFD KTDEDYNENS
DEEVDINLQD DEFVIEGESE VGPLKMHILP LYSLLPTKEQ LKVFEPPPTD SRLVILATNI
AETSLTIPGV RYVFDSGRSK ERKFDKLTGV QSFEIGWISK ASAQQRAGRA GRTIAGHCYR
LYSSAVYERD FPEVSEPEIL RMPIEGVVLQ LKAMNLQKVM SFPFPTPPER EILEKSERLL
KYLMALSTAG KITSTGLTMS LFPLPPRLSR ILLVGHLHDC LPYIIALVSG LSASGVFLSE
REVVPDLKPR DDTTYLANSE RIEEDLRIDI KRRFHRAQKG FCFLDDKSDA IKLLQAVGEF
AHEPTEAWCQ AHFVRYKTLK EIQNLRRQIT DLLRTNIDAF AAFRYEEKLK PPSEKQVKML
KQMVAAGFID QIAIRADISP NSPGFQRKPR RAIDVPYLTL FPSNISNDDE DCLVYIHPES
PLAHLSPQEC PEYIVYSYLQ RAAQATADSA KAPKIRMHCL TDITGNQLAA LTKGTPLLHY
GKPLKEVLPK FRANEDEKVR ECWVIPYLRP ESIGSSIGWP LPARKVTQRR IHGRGWVVE
//
