ID A0A0B1TLH6_OESDE Unreviewed; 1700 AA.
AC A0A0B1TLH6;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Immunoglobulin I-set domain protein {ECO:0000313|EMBL:KHJ96255.1};
GN ORFNames=OESDEN_03784 {ECO:0000313|EMBL:KHJ96255.1};
OS Oesophagostomum dentatum (Nodular worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Strongylidae; Oesophagostomum.
OX NCBI_TaxID=61180 {ECO:0000313|EMBL:KHJ96255.1, ECO:0000313|Proteomes:UP000053660};
RN [1] {ECO:0000313|EMBL:KHJ96255.1, ECO:0000313|Proteomes:UP000053660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OD-Hann {ECO:0000313|EMBL:KHJ96255.1,
RC ECO:0000313|Proteomes:UP000053660};
RA Mitreva M.;
RT "Draft genome of the hookworm Oesophagostomum dentatum.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR EMBL; KN549714; KHJ96255.1; -; Genomic_DNA.
DR Proteomes; UP000053660; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 13.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR PANTHER; PTHR14340:SF9; TITIN; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 8.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 9.
DR SMART; SM00408; IGc2; 7.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 8.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000053660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..53
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 58..148
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 248..342
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 348..442
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 448..536
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 541..634
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 639..732
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 786..1041
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1109..1197
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1232..1319
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1392..1479
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1508..1602
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1608..1690
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1359..1381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 815
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1700 AA; 189998 MW; A201670AC2F9D354 CRC64;
MWIKVSDYNI RDPEFTVPGL KEFHDYEFRI IAINAIGKGV PSLPTSPIKI QDLNGSRPMI
VVKPEDTAQP YNRRAVFVCE AVGRPEPVCR WMRNGRELPE SSRYRFEAHE GSYRFTIKEV
WDIDAGEYTC EVSNVYGSDT ATAKLIVQAP PVIEKDVPNT ILPMGEMVRL KIYFSGTPPF
KHSLTLNKEE IDSEHPTIRT VDFDDHILIT IPSLSTREAG RYEYVISNES GEDSTGFWLN
VTGLPSAPQG PLHFSEVGLH QVGLSWRPPV NDGGSKITNY VIEKRDTSKE EWTVVASSVR
DLSFVVQGLF ENHEYEFRVS AVNENGQGAP LVGENPVETR LPFDPPSPPL DPEVTEIGGD
FLSLTWRRPA SDGGGRLRGY YIEKCEEGSE TWVRCNQNPS PANIFNIPNL IDGRKYTFRV
LALNDAGLSE PALMEPMVFK AALGGTPPEV VRELSDQSGE PGRSATFECE ISGTPRPEYT
WFKGLKELVD TPRYTILSKG DVQVLMVNHM NSDDIGEYTC RATNKFGTRT TRAQLLLKQK
PRIFVPPRYH GGYEANKNET IELKMPYKAY PRAESRWMKD DEKIESGGRY TITTDDKFAT
LTISNATRED YGNYRVTVEN SVGQDSATVQ VTVADCPEPP RFPKVENVLD EAVILSWKPP
LLDGGSMVTQ YIVEKRDVNG GIWEPCAKTR YAYLTVEGCR PKTTYEFRIS AENKHGVSQP
CEPTAPVLIP GNERIRRKGY DVDDTGKVIH GKGPTLGNYD PYVIDIWKQY YPEPVEIKHD
SVLDHYDIHE EIGTGAFGVV HRCTERATGN TFAAKFINTP HEADKQTVRK EINTMSVLRH
PTLINLHDAF EEDKEMVMIY EFMSGGELFE KVADDSNRMT EAEAIDYTRQ VCKALCHMHE
MNYVHLDLKP ENIMFTTKKS NQLKLIDFGL ASYLDPKESV KVTTGTAEFA APEVANGDAV
GYYTDMWSVG VLAYILLSGL SPFGGENDEE TLKNVKKCDW NMDDSAFSGV SENARDFIRK
LLVLEPDKRM TVHEALAHPW LASGEVGGGD VIPSSRYTDF RDKIRMKYDA WPEPVPPLGR
ISNFSSLRKH RPAEYHIHDA FFDRSEAQPR FIIKPYSTTV TEGQSANFYC RVIAPSPPIV
TWHKDMTELK QSVKYMKKYN DNDYALTINR TKMDDKGEYV VRAKNQYGSK EEVVFLTVQK
KSEDFISKPL EPMKKGPALP RVEEFKEKEI APNFTFHLRP RLIQKNHQCK LICTLQGYPT
PKVEWFKDGS PVNQDRVQTT FRSGVCTLEI FNTRTDDAGT YSCTATSPLG EATTECTVTV
QTKAGEPMPR VSTYSSYRSS SSYKRSVYDT LGTREVERSR SYAEIRSESS SQSSETRSAA
DDLKMKISSE PPNFTSKLRD VSVGQGESVE MSCEVDATPS PLIEWLRNGE RVTDPRLVTS
YSGGKAILRI SEAEPSDAGE YMCKASNSAG SESCRAHLSV EAKANGAVNG VNGVNGCLLQ
ANLSIPLPYV SHSRIVRHLA GQIADADSTA TFEACVSGEP EQVTWTKNGT EVRSEDRVEI
ARDGERFRLT INGVKADDAG QYQLEVQEKG TKFITVASLS VSGAPNEPPV TKLPSSVSVA
SGSATKLVLE LSDAEGYTAQ WFKGADKVEK SERMKSVKSG NSFKLDFKTV QSTDEGVYVV
KVIKDKKAVA KYAAAIFVEP
//
