ID A0A0B2ABK9_9MICC Unreviewed; 703 AA.
AC A0A0B2ABK9;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=LK10_19325 {ECO:0000313|EMBL:KHL00594.1};
OS Sinomonas humi.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Sinomonas.
OX NCBI_TaxID=1338436 {ECO:0000313|EMBL:KHL00594.1, ECO:0000313|Proteomes:UP000030982};
RN [1] {ECO:0000313|EMBL:KHL00594.1, ECO:0000313|Proteomes:UP000030982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 117 {ECO:0000313|EMBL:KHL00594.1,
RC ECO:0000313|Proteomes:UP000030982};
RA Lee L.-H.;
RT "Genome sequence of Sinomonas sp. MUSC 117.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHL00594.1}.
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DR EMBL; JTDL01000150; KHL00594.1; -; Genomic_DNA.
DR RefSeq; WP_043127543.1; NZ_JTDL01000150.1.
DR AlphaFoldDB; A0A0B2ABK9; -.
DR STRING; 1338436.LK10_19325; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000030982; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000030982}.
FT DOMAIN 14..294
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 295..551
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT DOMAIN 630..703
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT BINDING 35..42
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 703 AA; 76074 MW; 683A643084521890 CRC64;
MTSEVQSLED RLLGGLDDEQ RTVATTLQGP LCVLAGAGTG KTRAITHRIA YGVHAGVYQP
QRLLAVTFTS RAAAEMRSRL RDLGVGGVQA RTFHAAALRQ LQYFWPQAVG GQLPGLLEHK
AQAIAEAARR LRLTVDRAAI RDLASEIEWA KVSMLTPSTY LQGAAGRGEP GGLQPPTVAR
LFQAYEDVKI DRNLIDFEDV LLVTVGILQE DPKVAAEVRE QYRYFVVDEY QDVSPLQQRL
LELWLGGREE LCVVGDASQT IYSFTGATSA HLLEFGQRFP AATVVKLVRD YRSTPQVVDL
ANRLLGARRS SGPAADRLWA EPLQLLAQRP AGPAPEFAEC SDDEAEAAAV AQRISKLVAA
GTEPKDIAVL FRTNGQSEAF EQALTAAGIG YQLRGGERFF NRREVRDALL QLRGAARTQP
TGISLGQAVR DVLSSLGYAD TAPSGSGATR ERWESLSALV ALADELSASR GEAFGMPEFV
LELHERSAAQ HAPAVQGVTL ASLHAAKGLE WDAVFLVGLS EGLVPISFAD TPTTVDEERR
LLYVGITRAR EFLHLSWSLS RTPGGRAHRR PSRFLDGLRP GSLRTTASAA GSSSARRRRE
YRGPAVCRVC GTVLESGAER KVGRCADCPP SYDEGTFESL RAWRLEQARE ADVPAFVVFT
DATLTAIAEA RPGSLDDLAK VAGVGKAKLE RYGDAVLELL RGA
//
