ID   A0A0B2UTU5_TOXCA        Unreviewed;      1346 AA.
AC   A0A0B2UTU5;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=5-oxoprolinase {ECO:0000313|EMBL:KHN74521.1};
GN   Name=OPLAH {ECO:0000313|EMBL:KHN74521.1};
GN   ORFNames=Tcan_16095 {ECO:0000313|EMBL:KHN74521.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN74521.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN74521.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN74521.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN74521.1}.
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DR   EMBL; JPKZ01002898; KHN74521.1; -; Genomic_DNA.
DR   STRING; 6265.A0A0B2UTU5; -.
DR   OMA; TDCNVML; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 2.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT   DOMAIN          1..136
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          156..456
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          505..615
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          633..794
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          817..1340
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
SQ   SEQUENCE   1346 AA;  146339 MW;  DE85EF28E14E8FDF CRC64;
     MGTTVATNAL LERKGERCAL LITKGFKDLL YIGNQTRPSI FEFDICLPDV LYEEVIEVDE
     RVIVADDTCQ LDLNAPKDQA RNLEEVFVEK AVDEGLVKQQ LKWIYDKGIR SLAVVFLHSY
     KYPNHEKQVG EIAAKMGFSN ISLSSDVMPM IKIVPRGYTA CADAYLTPKI REYINSFNAG
     FIDDLKGVRV EFMQSDGGLC PVEKFFGSRA ILSGPAAGVV GVSLTAYDVL TKQPIIGFDM
     GGTSTDVSRY AGSFAHVMET AIAGVTIQAP QLDIHTVAAG GGSRLFFRSG LFEVGPESAC
     ATPGPVCYRK NGYLAVTDAN LVLGRIIPDY FPHIFGESEN EPLDRAAALE AMQHITDEAN
     AFYSAHVDVS RPPMSVEEVA LGFIDVANET MCRAIRSITQ AKGHDTSRHV LACFGGAGGQ
     HACAIAKSLG MKSVFIHRYS GILSAYGLAL ADAVHEAQEP AAKVFSKASS DQSMECYEES
     FNEAYKREFG FTIPGREIIV DDIRAAALEA MQHITDEANA FYSAHVDVSR PPMSVEEVAL
     GFIDVANETM CRAIRSITQA KGHDTSRHVL ACFGGAGGQH ACAIAKSLGM KSVFIHRYSG
     ILSAYGLALA DVVHEAQEPA AKVFSKENFE YFRDRLKSLM EQCRNELKKI GFTDELIRYE
     PFLYMRYSRT DCSLMCSPSA SSDQSMECYE ESFNEAYKRE FGFTIPGREI IVDDIRVRGV
     GMSRKTDHIK IAKAVEPENP PLKTTTLCCF KEGKLETKVF DLSELHFGHI MHGPCIIVDA
     NSTIVVEPRC EATITEEGNI CIAIGDQAQR DIGVDIDPIQ LSIFSHRFMS IAEQMGQILQ
     RTAISTNIKE RLDFSCALFG PDGGLVANAP HIPVHLGGMQ ATVRFQIEHL GIEGMHDGDV
     ILCNHPKAGG SHLPDLTVIT PVYYKGSERP VFFVANRGHH ADIGGLVPGS MPPHSTCLQQ
     EGAAFVSFKL VDQGRLQEAK LIELLNAPGN VPGCSGTRNL SDNLSDLRAQ IAANQKGIGL
     VCELIECYGL DVVHAYMAHI QNNAEMAVRN LLKQVGRKRR EETGIAILSA VDYMDDGTPI
     CLSVQIDDEK GEAIFDFEGT GPEVHSSCNA PPAVTMAAVI YCLRCLVGSE IPLNQGCLTP
     ITIKIPSGTI LSPDETAAVV GGNVLTSQRL CDVILLAFNA VAASQGCMNN LTFGDDRMGY
     YETVAGGAGA GPGFDGRSAI HTHMTNTRIT DPEILETRYP VILREFSIRK RSGGDGEFRG
     GDGCIRRMQF RRPLQLSVLT ERRAFAPYGL AGGRPGQRGL NLLHRRSGRT VNLGGKNCVD
     VCAGDSLELR TPGGGGYGQP KRTTHS
//