ID A0A0B2VAU2_TOXCA Unreviewed; 804 AA.
AC A0A0B2VAU2;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Protein transport protein Sec24B {ECO:0000313|EMBL:KHN80621.1};
GN Name=SEC24B {ECO:0000313|EMBL:KHN80621.1};
GN ORFNames=Tcan_13354 {ECO:0000313|EMBL:KHN80621.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN80621.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN80621.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN80621.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN80621.1}.
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DR EMBL; JPKZ01001702; KHN80621.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VAU2; -.
DR STRING; 6265.A0A0B2VAU2; -.
DR OMA; AVECSKQ; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF39; SECRETORY 24AB, ISOFORM A; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 2.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 121..157
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 195..353
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 392..464
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 471..555
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 568..656
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
SQ SEQUENCE 804 AA; 90107 MW; E0E28A31EC1BE738 CRC64;
MCISGLRMVN NTITATRFHS SPGISVRPLA ECSDAALHHS RFVDLMQRRD LLSVHLDDTD
IAVPSSVCNP TAFSTPGALR CTLRSVPQTQ KLLKKSCLPF GLILKPFGST EDVDVIDVST
IVRCRCCRAY INPYIYLPDT RHWQCNLCQK LNELPDDFIL NSRNKPLEKG ALRPELRSGS
VEFIASSEFT SHPPHTFVYI FVLDVSHAAV ESGYLSTFAE QMLQSLERMP SNERTLISIL
AVDAALHFFQ FNEGASPRHI IVDDIQDPFI PVSSGLLVHL QDNIKVIAAF VQNLPLLFES
NSSRSNCLGA ALDVACELMQ DFGGRITVIQ TVLPNIGPGA LASREDAHSE ASLTEDDLEQ
PLCTCLVLAY VGRSGCSSIV RIAYTQMMDG RTLRPSTDFY KNFALRCLDL EIAVDLFLLS
TRYADLATLA EMAKFSGGTS YFYRGYDVND EQLQQKRFEA QLADYLTRDI GFEAMLRIRC
SEGIAPHSFY GNFFVRSIDL MVMGNVNPHS AIGVKLEMQD DFSTLSNVSF QAALVYTSSK
GVRRVRVHTL CLPLTKDLLT VYSDFDAKCA ITLLSKIGSM SDCQEAMTNS LADVLKAFNT
AVVHQSHTSL LLSPGGSMRL LPLYILAMLK HRGFSIERTI RLDERVSALL LFRTASSEIV
ELELYPALYK LNQFTAGEED PSRLHLSYEF IDPDGLYLLD VGSYVYIYVM AAVGQVLVKD
LFGVDCFKKI DEQKELRPTE NIFSQRVHNF IRKLSIQRAM LPPVLVIRED GSMRNTFIDR
LIEDRTQLSQ SYADFLHYLH HKVQ
//
