ID A0A0B2VAX5_TOXCA Unreviewed; 438 AA.
AC A0A0B2VAX5;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Sterile alpha and TIR motif-containing protein tir-1 {ECO:0000313|EMBL:KHN78658.1};
GN Name=tir-1 {ECO:0000313|EMBL:KHN78658.1};
GN ORFNames=Tcan_09275 {ECO:0000313|EMBL:KHN78658.1}, TCNE_LOCUS10721
GN {ECO:0000313|EMBL:VDM42042.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN78658.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN78658.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN78658.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:TCNE_0001072101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDM42042.1, ECO:0000313|Proteomes:UP000267007}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JPKZ01002071; KHN78658.1; -; Genomic_DNA.
DR EMBL; UYWY01020594; VDM42042.1; -; Genomic_DNA.
DR STRING; 6265.A0A0B2VAX5; -.
DR WBParaSite; TCNE_0001072101-mRNA-1; TCNE_0001072101-mRNA-1; TCNE_0001072101.
DR OMA; FDQHFEF; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR Proteomes; UP000050794; Unplaced.
DR Proteomes; UP000267007; Unassembled WGS sequence.
DR GO; GO:0003953; F:NAD+ nucleosidase activity; IEA:InterPro.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0034128; P:negative regulation of MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048678; P:response to axon injury; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09502; SAM_SARM1-like_repeat2; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR039184; SARM1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR22998:SF1; NAD(+) HYDROLASE SARM1; 1.
DR PANTHER; PTHR22998; SARM1; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 75..139
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 221..366
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 366..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 49882 MW; DEEC2C1F6B06593D CRC64;
MAKPCFKMAR YRLSRTKRLL AKPYDNENIK EIGAIAALKE VASSPDEVAA KFASEALTVI
GEEVPYKLTQ QVPCWTIADV QYWVKKIGFE SYAEGFAKHM VDGDLLLLLT EKELEQDLQM
TSALHRKRFI RELESLKIAA DYGSVDESQL DQFLMSLSPE LSVYTYQMLG MGLNRSLLPS
LTDEMMKTVC GITNPIHRLK LRQALQDSKH IDDIEVAILS KQIDVFISYR RSTGNQLASL
IKVLLQLRGY KVFIDVDKLY AGKFDSSLLK NIQAAKHFIL VLTPNSLDRL FNDNNCEDWI
HKELRCAFEH HKNVIPIFDQ HFEFPAVDTE IPADIRPITK YNGVRWVHDY QEACMDKVER
FIKGELNRTP SIGQQQPSVT SSTSSQRRSQ STRWTSSNVR SATQKCAISR QQLEPSTHHC
TSPRPPLRSS AANSVTRP
//
