ID A0A0B2VE94_TOXCA Unreviewed; 822 AA.
AC A0A0B2VE94;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 6 {ECO:0000313|EMBL:KHN79764.1};
GN Name=TRPV6 {ECO:0000313|EMBL:KHN79764.1};
GN ORFNames=Tcan_15065 {ECO:0000313|EMBL:KHN79764.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN79764.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN79764.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN79764.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN79764.1}.
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DR EMBL; JPKZ01001850; KHN79764.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VE94; -.
DR STRING; 6265.A0A0B2VE94; -.
DR OMA; YQYLHQN; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR PANTHER; PTHR10582:SF22; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KHN79764.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 413..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 184..216
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 285..317
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 585..729
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 777..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 822 AA; 95109 MW; 70F40B6BBD7FF175 CRC64;
MSKLVERSSI EEEKVYQLVD CHGDGILMPW IKYAQQTNDY GVLDEYLETV VKSFLYNGGK
GKLISISELV MIRNKQRNAM LSALRRKKGR GKCGPNILDD INQEGAQQGD VIKALKILDG
CIRGNRSMNY RELIWDITLR GKMGENLLHI CMLHNTADHN ELVRLIVKKY PKMVNDVFIS
EDYYGLSPLH QAIVNEDIEM VYFLLRHKAD VHQRCYGSFF CADDQKASRT DSLEHEWVDL
VQNSRFTGRM YWGEYPLSFA ACTNQHDCFR LLRACNADPN MRDTNGNTVL HLAVIHELRE
MFVLAYELGA RLDVKNNQKL TPMALAAKLA KKEMFDLILD MERDVLWNYG NVTCTAFPLG
DIDTVDQRTG HLNQASVLSL VVYGEKSRHL DFLDGLLEDL LEAKWTAFGR TRFLFSLAYY
IVYVLSFYVA FMAREFSATK AEEDIWSSNP FNASNQDSWA FTYEEIVYMQ RVDEEKSQPL
QCHLWEYHDR DGSFSQRALK FQIRLICECI ILILALKQSL QEVVDILRSG HRRWWKIMRA
FPSKILHTLS FAIVLLIVGV RFACGLHPHV FILENVLAIG AVLTTSMHFL FYCRGMRFVG
PFVLMVYKII VGDILRFFLI YLIFVIGFSQ AFFVMFIGCE REHHERMARN ETSNFENILV
GSFESLMIMF IMSVGEFTSF YNTLNDCSSS LVPIGKVIFL IYELLVTVML LNLLIAMMTR
TYEKISETQK EWKRQWAQVI LLLEQTLQPR DRLIAMLKYS RPIRSDKRHR AFVVRQRVSP
HEPKAKTEVV GRERKTGTDA GSSESKDKTS IKQQPLLVTH LV
//
