ID A0A0B2VLT7_TOXCA Unreviewed; 902 AA.
AC A0A0B2VLT7;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Histone-lysine N-methyltransferase 2C {ECO:0000313|EMBL:KHN82304.1};
GN Name=Kmt2c {ECO:0000313|EMBL:KHN82304.1};
GN ORFNames=Tcan_09257 {ECO:0000313|EMBL:KHN82304.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN82304.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN82304.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN82304.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN82304.1}.
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DR EMBL; JPKZ01001384; KHN82304.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VLT7; -.
DR STRING; 6265.A0A0B2VLT7; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15514; PHD6_KMT2C_like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF6; HL01030P-RELATED; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:KHN82304.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:KHN82304.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 288..341
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 358..422
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 73..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 98652 MW; 95ED14B901341CC1 CRC64;
MDEVHGSVAV SSASTSVLSP GAQRVHRIDA FATRWIHTEC DADALGGGAV EGEYVCAVCR
NSPLVADAMM TSAGSSSLAP SPTSVSAHDE TSRNTLETGF SIQSPTNRNS PLAPLSHLDS
TFNDIFTISH ASGHGDVSSM SSPATTTATT TASNSARASP AFFLDNTASS DTDDFRPPPR
GGKTSSMIAL VASTAAGREA ELHTQENGDT EESKNRVEDN EYIRTVVITS AENTFFMQMP
VCLICGSIGK DIEGTMVACA TCAQSYHTFC VGLHDKLNST IVKRGWRCLD CTVCEGCGDG
RDESNLLLCD ECDVSYHIYC LDPPLERIPH GSWRCKWCAT CRRCSAPIPS AVDTQRMEGL
CETCYSLRKC PKCLRLYEVG EHIIKCQHCS RWLHGKCEDI CGEDMLEAAA ENGFRCSLCR
PQGNTPASDA LNVLICDYVP MNKCALDVLH TKHGGSLFRS TSLQEPMFDL PMHPFASRGH
SFDDAYEEEE MEVVSVGMSG RGRGMRGGGP GRKVLKLGVG DAYEEEEMEV VSVGMSGRGR
GMRGGGPGRK VLKLGVGGFF VKMPRHRIQA AEDDANAEEE LAPGQKPKIK RPRKPRRCQL
EDNYPPIIQE SFFGMRPVEG RNLLEVVVDE PNLSQEINKT TLGQEKQKEV FELNEADSEA
LREGESLLGD ITENDIFGNM EEIDFDNFDI NELLMEGEDE DDEDTLDAAT NDGGTASEDT
SATQSQQQFA FRVPQQGRNS GGQGQGGHHQ TGAHSGGAYP LQTSIQSAGS RSNSQMGENY
VERVNQATER WEEDEPLGER ATKAAVLYAN VNYPQWKKEY PEWCERVKHI HRMWRSLDAN
SRQEYVNKAR ENRANRAKQP RLKRLAPTLL RASVGSPKSG SPTRGGYFAS QVCLVQLFAV
AF
//
