ID A0A0B2VN02_TOXCA Unreviewed; 459 AA.
AC A0A0B2VN02;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Bone morphogenetic protein 4 {ECO:0000313|EMBL:KHN82425.1};
GN Name=BMP4 {ECO:0000313|EMBL:KHN82425.1};
GN ORFNames=Tcan_06198 {ECO:0000313|EMBL:KHN82425.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN82425.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN82425.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN82425.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN82425.1}.
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DR EMBL; JPKZ01001364; KHN82425.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VN02; -.
DR STRING; 6265.A0A0B2VN02; -.
DR OMA; SIYFFED; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13761; TGF_beta_BMP5_like; 1.
DR Gene3D; 2.60.120.970; -; 2.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF263; PROTEIN DECAPENTAPLEGIC; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 338..459
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 328..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..350
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 52948 MW; F79CA20EF66D99E7 CRC64;
MTLSLSSSSS SSSAGPQAFR LRPLVKCCSP PVPILRNPRR HCRTTTFYVL VLITLLPPPP
LSNAHKASIS NSNKSRFTTA EIDLIRRSFL KKFGMKEQPK QQLPVVPVPN YMWDIYDKVQ
NEEVEWVRHY YPQRIMENKD RLLLLRYNLT VSVQNATNER VLRADLKLKL NRGIAKRRVK
VYEVDQRNPD IRRLLLLRYN LTVSVQNATN ERVLRADLKL KLNRGIAKRR VKVYEVDQRN
PDIRRLLDSR QIEPEPKKDH QWVDMDVSEA LTRRRPDRSR VDFAVELSDG HLTSRTPPSA
ATISATPYSR TQAAALVVYV ETNDETAKVR RKRRAGGKRR HQHRKHNHRV GSMEKNLCQR
RELHVDFNEL NWQDWILAPP SYSAYQCQGE CPNPLTGHFN TTNHAIVQGL INSVNPSQVP
APCCVPIEME SLAILYIDVE SKIVIKNYPD MEVISCGCR
//
