ID A0A0B2VSU7_TOXCA Unreviewed; 657 AA.
AC A0A0B2VSU7;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 22-FEB-2023, entry version 17.
DE RecName: Full=Trehalase {ECO:0000256|ARBA:ARBA00019905, ECO:0000256|RuleBase:RU361180};
DE EC=3.2.1.28 {ECO:0000256|ARBA:ARBA00012757, ECO:0000256|RuleBase:RU361180};
DE AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
GN Name=TREH {ECO:0000313|EMBL:KHN86621.1};
GN ORFNames=Tcan_04498 {ECO:0000313|EMBL:KHN86621.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN86621.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN86621.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN86621.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC Evidence={ECO:0000256|ARBA:ARBA00001576,
CC ECO:0000256|RuleBase:RU361180};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN86621.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPKZ01000540; KHN86621.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VSU7; -.
DR STRING; 6265.A0A0B2VSU7; -.
DR OMA; DVYFYWD; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR001661; Glyco_hydro_37.
DR InterPro; IPR018232; Glyco_hydro_37_CS.
DR PANTHER; PTHR23403; TREHALASE; 1.
DR PANTHER; PTHR23403:SF3; TREHALASE; 1.
DR Pfam; PF01204; Trehalase; 1.
DR PRINTS; PR00744; GLHYDRLASE37.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR PROSITE; PS00928; TREHALASE_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..657
FT /note="Trehalase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002095579"
FT TRANSMEM 606..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 657 AA; 75062 MW; 8DE19F2A0E6ED98B CRC64;
MPAWPVVVAL AALPFAPWAI HVGVSSPDAK RSASREKSHV DVLHEPVLPN CTEPICIGPL
ASIYCSGGLI HASWMFGLQD TCPGDMMLQT PDAVIAAFNK LKYPLKRDDF KRFCTDNFMN
FPYLKAAKLS DWMEEPPNLR SIKDDRLRKL AKKLNDIWKF LGREFDEKVK ENPDLFPVLT
VPNSFVVPGG LFQMYFYWDS YWIIKGLIFS NMTLTARHMI ENFASVIQYH GFIPNSGNVQ
LSRRSQPPLF VQMLADYYYL TRNKTFLSSI LPLVDIELSW WLRNRSVILS SNFGEYTMFH
FHAASNCPRP ENYLVDLRNG LEGTGGAKFI WSSIASACES GLDFSSRWFA YTGPHARTKF
SIRTNSIIPV DLNTFMVWNY DTTADLYLEL GLERKSENYR KLAADLWKSI ETVLWNESEG
VWLDYDLSKQ EHRRKFYPSN VFPLLTGRST LHIADRILYY LRSSGALDFR GGIPSTLDDS
SHEQWDFPNG WAPSIHLFVE SLRRSSHPSL FDVAVQTADK FIRTVYNGLF NPVGEWPPAC
WEKYDIRYDD GRPGVSGEYP VQQGFGWTNG AVLDMILRFH VDKDEPFLLP SEGFVLTFGH
SPHAPVIALA FIICITFSAW FAYQALGNRH VKLKKGVWLA TGLAEESRLI DEFEEDS
//
