ID A0A0B2VYU4_TOXCA Unreviewed; 420 AA.
AC A0A0B2VYU4;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 03-MAY-2023, entry version 21.
DE RecName: Full=Hsp90 chaperone protein kinase-targeting subunit {ECO:0000256|ARBA:ARBA00031396};
GN Name=cdc-37 {ECO:0000313|EMBL:KHN88711.1};
GN ORFNames=Tcan_11569 {ECO:0000313|EMBL:KHN88711.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN88711.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN88711.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN88711.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the CDC37 family.
CC {ECO:0000256|ARBA:ARBA00006222}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN88711.1}.
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DR EMBL; JPKZ01000189; KHN88711.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VYU4; -.
DR STRING; 6265.A0A0B2VYU4; -.
DR OMA; CINLEME; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR Gene3D; 6.10.140.250; -; 1.
DR Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR InterPro; IPR004918; Cdc37.
DR InterPro; IPR013873; Cdc37_C.
DR InterPro; IPR013874; Cdc37_Hsp90-bd.
DR InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR InterPro; IPR013855; Cdc37_N_dom.
DR PANTHER; PTHR12800; CDC37-RELATED; 1.
DR PANTHER; PTHR12800:SF4; HSP90 CO-CHAPERONE CDC37; 1.
DR Pfam; PF08564; CDC37_C; 1.
DR Pfam; PF08565; CDC37_M; 1.
DR Pfam; PF03234; CDC37_N; 1.
DR SMART; SM01069; CDC37_C; 1.
DR SMART; SM01070; CDC37_M; 1.
DR SMART; SM01071; CDC37_N; 1.
DR SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT DOMAIN 57..180
FT /note="Cdc37 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01071"
FT DOMAIN 178..340
FT /note="Cdc37 Hsp90 binding"
FT /evidence="ECO:0000259|SMART:SM01070"
FT DOMAIN 346..415
FT /note="Cdc37 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01069"
FT COILED 129..164
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 420 AA; 49233 MW; 05EF173420540068 CRC64;
MLSQRHSTLP DVFPRRTDEA WKMLWCPVFT GQFLLFVTQS KINVEWLFSL HHVWKMPLDY
SKWKNIEVSD DEDDTHPNID TPSLFRWRHQ ARMERMAERK QEKEEITKGK TNVEKRMLEI
EEKLKSTGLD EKERIKLELE RDEVKKQEED YLKKEKELEE KERLEPWNVD TIGHEAFSSS
RINKVTEKRP QQPKMTYEEE TKRMADYFDS NGELLKEFGS LKGLDASEKF LLEHPHIASE
FAANFLTIEA LNMAIEMKED EMSNYAEQCI IVQYLLELSK SLHALATNTN VIKNFFKKFR
SADPEYLKSY RAEVEAFKDR LRKRAKDKRD AAIEEYEAEE KAKRIAASPG GVDPQEVYDS
LPPEMKEAFD SQDVARLQAV AQSMDQEVFC HHLKRCIDSG LWIPDANAHN EADGTATKNE
//
