ID A0A0B4J1A6_DANRE Unreviewed; 598 AA.
AC A0A0B4J1A6; A0A8M1NAV6;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Insulin-like growth factor 2 mRNA-binding protein 1 {ECO:0000256|ARBA:ARBA00014056};
DE AltName: Full=IGF-II mRNA-binding protein 1 {ECO:0000256|ARBA:ARBA00030731};
DE AltName: Full=VICKZ family member 1 {ECO:0000256|ARBA:ARBA00029880};
GN Name=igf2bp1 {ECO:0000313|Ensembl:ENSDARP00000082159,
GN ECO:0000313|RefSeq:NP_001070027.2,
GN ECO:0000313|ZFIN:ZDB-GENE-060929-1258};
GN Synonyms=CRDBP {ECO:0000313|RefSeq:NP_001070027.2}, fb96d05
GN {ECO:0000313|RefSeq:NP_001070027.2}, IMP1
GN {ECO:0000313|RefSeq:NP_001070027.2}, wu:fb18f03
GN {ECO:0000313|RefSeq:NP_001070027.2}, wu:fb96d05
GN {ECO:0000313|RefSeq:NP_001070027.2}, wu:fi72a06
GN {ECO:0000313|RefSeq:NP_001070027.2}, zgc:152963
GN {ECO:0000313|RefSeq:NP_001070027.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000082159};
RN [1] {ECO:0000313|RefSeq:NP_001070027.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070027.2};
RX PubMed=15601260; DOI=10.1042/BC20040151;
RA Yisraeli J.K.;
RT "VICKZ proteins: a multi-talented family of regulatory RNA-binding
RT proteins.";
RL Biol. Cell 97:87-96(2005).
RN [2] {ECO:0000313|RefSeq:NP_001070027.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070027.2};
RX PubMed=17640903;
RA Wang D., Jao L.E., Zheng N., Dolan K., Ivey J., Zonies S., Wu X., Wu K.,
RA Yang H., Meng Q., Zhu Z., Zhang B., Lin S., Burgess S.M.;
RT "Efficient genome-wide mutagenesis of zebrafish genes by retroviral
RT insertions.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:12428-12433(2007).
RN [3] {ECO:0000313|RefSeq:NP_001070027.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070027.2};
RX PubMed=18803835;
RA Sundstrom G., Larsson T.A., Larhammar D.;
RT "Phylogenetic and chromosomal analyses of multiple gene families syntenic
RT with vertebrate Hox clusters.";
RL BMC Evol. Biol. 8:254-254(2008).
RN [4] {ECO:0000313|RefSeq:NP_001070027.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070027.2};
RX PubMed=18550893; DOI=10.1074/mcp.m800081-mcp200;
RA Lemeer S., Jopling C., Gouw J., Mohammed S., Heck A.J., Slijper M.,
RA den Hertog J.;
RT "Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown
RT embryos.";
RL Mol. Cell. Proteomics 7:2176-2187(2008).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000082159, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000082159};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|RefSeq:NP_001070027.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070027.2};
RX PubMed=25389298;
RA Barnes M., van Rensburg G., Li W.M., Mehmood K., Mackedenski S., Chan C.M.,
RA King D.T., Miller A.L., Lee C.H.;
RT "Molecular insights into the coding region determinant-binding protein-RNA
RT interaction through site-directed mutagenesis in the heterogeneous nuclear
RT ribonucleoprotein-K-homology domains.";
RL J. Biol. Chem. 290:625-639(2015).
RN [7] {ECO:0000313|RefSeq:NP_001070027.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070027.2};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [8] {ECO:0000313|RefSeq:NP_001070027.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070027.2};
RX PubMed=26325373;
RA Gaynes J.A., Otsuna H., Campbell D.S., Manfredi J.P., Levine E.M.,
RA Chien C.B.;
RT "The RNA Binding Protein Igf2bp1 Is Required for Zebrafish RGC Axon
RT Outgrowth In Vivo.";
RL PLoS ONE 10:e0134751-e0134751(2015).
RN [9] {ECO:0000313|Ensembl:ENSDARP00000082159}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000082159};
RG Ensembl;
RL Submitted (JAN-2015) to UniProtKB.
RN [10] {ECO:0000313|RefSeq:NP_001070027.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070027.2};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [11] {ECO:0000313|RefSeq:NP_001070027.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070027.2};
RX PubMed=29136572;
RA Dong X., Xu H., Wu X., Yang L.;
RT "Multiple bioanalytical method to reveal developmental biological responses
RT in zebrafish embryos exposed to triclocarban.";
RL Chemosphere 193:251-258(2018).
RN [12] {ECO:0000313|RefSeq:NP_001070027.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070027.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM IMP/VICKZ family.
CC {ECO:0000256|ARBA:ARBA00009094}.
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DR EMBL; BX682553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX682558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001070027.2; NM_001076559.2.
DR Ensembl; ENSDART00000087726.7; ENSDARP00000082159.4; ENSDARG00000061478.8.
DR Ensembl; ENSDART00000176012.2; ENSDARP00000143837.1; ENSDARG00000061478.8.
DR GeneID; 558182; -.
DR KEGG; dre:558182; -.
DR AGR; ZFIN:ZDB-GENE-060929-1258; -.
DR CTD; 10642; -.
DR ZFIN; ZDB-GENE-060929-1258; igf2bp1.
DR HOGENOM; CLU_020744_1_0_1; -.
DR OMA; YIPDEQT; -.
DR OrthoDB; 3035007at2759; -.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000061478; Expressed in tail bud paraxial mesoderm and 26 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd22490; KH-I_IGF2BP1_rpt1; 1.
DR CDD; cd22493; KH-I_IGF2BP1_rpt2; 1.
DR CDD; cd22496; KH-I_IGF2BP1_rpt3; 1.
DR CDD; cd22499; KH-I_IGF2BP1_rpt4; 1.
DR CDD; cd12625; RRM1_IGF2BP1; 1.
DR CDD; cd12630; RRM2_IGF2BP3; 1.
DR Gene3D; 3.30.310.210; -; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR034837; IGF2BP1_RRM1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR10288:SF92; INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 4.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00322; KH; 4.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 4.
DR PROSITE; PS50102; RRM; 2.
PE 1: Evidence at protein level;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0B4J1A6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..75
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 81..156
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 155..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 65590 MW; CA78CFDC29CDE7DC CRC64;
MNKLYIGNLN EKVTAEDLVK TFEDYKIPYS GQFLMKTGYA FVDCPDDQWA MKAIETFSGK
VELHGKRIEV EHSVPKKQRT RKLQIRNIPP HLQWEVLDGL LAQYGTVENC EQVNTDSETA
VVNVTYGTRE QARQAIQKLN GYQFDNNALR VSYIPDENSE VDSQRGPDNG RRPGYGPRGT
SRQMSPGSGI PSKHQHADIP LRLLVPTQYV GAIIGKEGAT IRNITKQTQS KIDVHRKENA
GAAEKPISIH STPEGCSAAC RMILEIMNQE AKDTKTADEV PLKVLAHNNF VGRLIGKEGR
NLKKVEQDTD TKITISPLQD LTLYNPERTI TVKGSIEACC LAEQEIMKKV REAYDNDIAA
MNQQTHLIPG LNLGAIGLFP PSSAMPPPAL GNSVPGPPYG PMGASEQETV HVYIPAQAVG
ALIGKKGQHI KQLSRFAGAS IKIAPAEAPD SKMRMVIVTG PPEAQFKAQG RIYGKLKEEN
FFGPKEEVKL ETHIKVAAAA AGRVIGKGGK TVNELQNLTA AEVVVPREQT PDEHDQVIVK
IIGHFYASQL AQRKIRDILT QVKQQQKGGG MGTPQGPHPQ GMTELGSPQG LAQEPRRK
//
