ID A0A0B5DF84_9ACTN Unreviewed; 720 AA.
AC A0A0B5DF84;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Dipeptidyl-peptidase-4 {ECO:0000313|EMBL:MBB4793639.1};
DE EC=3.4.14.5 {ECO:0000313|EMBL:MBB4793639.1};
DE SubName: Full=Peptidase S9 {ECO:0000313|EMBL:AJE42348.1};
DE SubName: Full=S9 family peptidase {ECO:0000313|EMBL:QEV40866.1};
GN ORFNames=BJY54_004251 {ECO:0000313|EMBL:MBB4793639.1}, CP978_21960
GN {ECO:0000313|EMBL:QEV40866.1}, SNOD_21630
GN {ECO:0000313|EMBL:AJE42348.1};
OS Streptomyces nodosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=40318 {ECO:0000313|EMBL:AJE42348.1, ECO:0000313|Proteomes:UP000031526};
RN [1] {ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|Proteomes:UP000031526};
RA Sweeney P., Stephens N., Murphy C., Caffrey P.;
RT "Sequence of the Streptomyces nodosus genome.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AJE42348.1, ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:AJE42348.1,
RC ECO:0000313|Proteomes:UP000031526};
RX PubMed=26497174;
RA Sweeney P., Murphy C.D., Caffrey P.;
RT "Exploiting the genome sequence of Streptomyces nodosus for enhanced
RT antibiotic production.";
RL Appl. Microbiol. Biotechnol. 100:1285-1295(2016).
RN [3] {ECO:0000313|EMBL:QEV40866.1, ECO:0000313|Proteomes:UP000325763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:QEV40866.1,
RC ECO:0000313|Proteomes:UP000325763};
RA Lee N., Cho B.-K.;
RT "Streptomyces genome completion.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:MBB4793639.1, ECO:0000313|Proteomes:UP000544950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40109 {ECO:0000313|EMBL:MBB4793639.1,
RC ECO:0000313|Proteomes:UP000544950};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP009313; AJE42348.1; -; Genomic_DNA.
DR EMBL; JACHMR010000001; MBB4793639.1; -; Genomic_DNA.
DR EMBL; CP023747; QEV40866.1; -; Genomic_DNA.
DR RefSeq; WP_043443597.1; NZ_JACHMR010000001.1.
DR STRING; 40318.SNOD_21630; -.
DR MEROPS; S09.073; -.
DR KEGG; snq:CP978_21960; -.
DR HOGENOM; CLU_006105_2_1_11; -.
DR OrthoDB; 9812921at2; -.
DR Proteomes; UP000031526; Chromosome.
DR Proteomes; UP000325763; Chromosome.
DR Proteomes; UP000544950; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF193; DIPEPTIDYL PEPTIDASE 9; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF07676; PD40; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:MBB4793639.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031526}.
FT DOMAIN 112..408
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 506..707
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 77780 MW; 07A4980E5D201769 CRC64;
MTTESASFPR QHARTQRFTL GAPRLFSASP DGSRVAFLRS SSGTDRSHQL WVLDPADGTE
RPVADPRALL GGSDEQLPPE ELARRERSRE GGAGIVGYAT DSAVELASFA LSGRLFTAEL
RAGTTRELPV SGPVIDPRPS PDGRHVAYVA RGALRVVGTD GEGDRALAEP EPTDGQGTVS
YGLAEFIAAE EMSRSRGFWW SPESDRLLVA RVDDTPVRRW WISDPARPAR EPRQVAYPAA
GTDNAEVRLF VLGLDGARTE VAWDRSGYPY LARVHWSAAG APLILVQSRD QRGQLFLAVN
PDTGETRMVH AEEDPNWLEL FPGVPCWSPS GQLVRISDEG GARVLAVGER PLTGAQLQVR
AVLDVSDGDV LVAASAGETA TDPEIGEVHV YRVNELGVER VSQEPGVHSA VRAGGLTVLV
SSVLGRPGAQ AQVLREGKVL ATVASYAERP ALSPRVRLTQ GGARRIPCAV LMPTDYSGDT
PLPVLMDPYG GPHGQRVMAA HNPYLTSQWF ADQGFAVIVA DGRGTPGRSP AWEQAVKDDI
AAVVLQDQVD ALHSLAGDFP LDLDRVAIRG WSFGGYLAAL AALRRPDVFH AAVVGAPVTD
LRLYDTHYQE RYLGDPERQP EVYRRNSLID DAGLVDAAEP ARPMMIIHGL ADDNVVVAHS
LRLSSALLAA GRPHEVLPLS GVTHMTPQEA VAENLLLLQR DFLRRALRLD REDTDREGRG
//
