ID A0A0B7HBQ9_9FLAO Unreviewed; 316 AA.
AC A0A0B7HBQ9;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=4-phosphoerythronate dehydrogenase {ECO:0000313|EMBL:CEN36009.1};
DE EC=1.1.1.290 {ECO:0000313|EMBL:CEN36009.1};
GN Name=pdxB {ECO:0000313|EMBL:CEN36009.1};
GN ORFNames=CCYN2B_30027 {ECO:0000313|EMBL:CEN36009.1};
OS Capnocytophaga cynodegmi.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Capnocytophaga.
OX NCBI_TaxID=28189 {ECO:0000313|EMBL:CEN36009.1, ECO:0000313|Proteomes:UP000038055};
RN [1] {ECO:0000313|Proteomes:UP000038055}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ccyn2B {ECO:0000313|Proteomes:UP000038055};
RA MANFREDI Pablo;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CDOD01000023; CEN36009.1; -; Genomic_DNA.
DR RefSeq; WP_041992302.1; NZ_CDOD01000023.1.
DR AlphaFoldDB; A0A0B7HBQ9; -.
DR STRING; 28189.CCYN74_90004; -.
DR eggNOG; COG0111; Bacteria.
DR Proteomes; UP000038055; Unassembled WGS sequence.
DR GO; GO:0033711; F:4-phosphoerythronate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd05303; PGDH_2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719,
KW ECO:0000313|EMBL:CEN36009.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000038055}.
FT DOMAIN 7..315
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 107..293
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 316 AA; 34482 MW; 2F5B45088F4019EF CRC64;
MKILANDGIS ELGKQHLEEN GFEVIVVKVA QNQLINYINQ NDINVLLVRS ATKVDKNIID
GCPSLKLIGR GGVGLDNVDI EYAKSKNIHV INTPVSSANS VAELVFAHLF SGARFLHDSN
RNMPLEGDTQ FNQLKKLYSN GVELRGKTLG IIGFGRVGQA VARMAIGLGM NVIAYDPNVK
EADIELPFFD GRTISFLVKT IEKEEVLKQS DFITINSPIQ DVYIIDSEEF ELMKEGVGVI
NLARGGVISE EALIEALESG KVSFAGLDVF ENEPTPSIRL LMHPNVSLTP HIGASTIEAQ
DRIGTELAEQ VVSLLK
//
