ID   A0A0B8NAT0_9NOCA        Unreviewed;      4588 AA.
AC   A0A0B8NAT0;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   SubName: Full=Peptide synthetase {ECO:0000313|EMBL:GAM45772.1};
GN   ORFNames=NS07_v2contig00019-0045 {ECO:0000313|EMBL:GAM45772.1};
OS   Nocardia seriolae.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=37332 {ECO:0000313|EMBL:GAM45772.1, ECO:0000313|Proteomes:UP000019401};
RN   [1] {ECO:0000313|EMBL:GAM45772.1, ECO:0000313|Proteomes:UP000019401}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N-2927 {ECO:0000313|EMBL:GAM45772.1,
RC   ECO:0000313|Proteomes:UP000019401};
RA   Imajoh M., Fukumoto Y., Yamane J., Sukeda M., Shimizu M., Ohnishi K.,
RA   Oshima S.;
RT   "Draft Genome Sequence of Nocardia seriolae Strain N-2927 (NBRC 110360),
RT   Isolated as the Causal Agent of Nocardiosis of Yellowtail (Seriola
RT   quinqueradiata) in Kochi Prefecture, Japan.";
RL   Genome Announc. 3:e00082-15(2015).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAM45772.1}.
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DR   EMBL; BAWD02000019; GAM45772.1; -; Genomic_DNA.
DR   STRING; 37332.NS506_05005; -.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000019401; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd17646; A_NRPS_AB3403-like; 1.
DR   CDD; cd19540; LCL_NRPS-like; 3.
DR   Gene3D; 3.30.300.30; -; 4.
DR   Gene3D; 3.40.50.980; -; 4.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 4.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR   PROSITE; PS00455; AMP_BINDING; 4.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019401}.
FT   DOMAIN          995..1070
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2068..2143
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3133..3209
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4231..4305
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          975..998
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3387..3420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3392..3413
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4588 AA;  493586 MW;  76F8618C011A668B CRC64;
     MSSLATDRVD QCSSGEFSAQ PFALSPAQSA LWYAQRIRPD IPLTIAQFVE IHGDLDVGRL
     LYAIERFGAE SEVGHVRLLE IDGVPHQVVD PSWRPGWARI DLREEPDPRA AARAWMNEHA
     SSPIDIERDP LTMNVVLRVG DSDWIWYTRG HHIVIDGYGA MNATTRAAEI YTALENQTEP
     VVSRAAPLAA IYGDENRYRD TSRFVTDSDY WREQLTGVGE PITLSGNGSL PVVSDGGRRT
     ATAVIGRDVE TAIEAAATAF GTNSSALFVA ALAGYVRAVT GTQDVVLSLP VSARTTVALR
     RSGGVVSNVV PIRVQFSATD TVADTVRAIE LQITGALRHQ RYRSDDIRRD CGYSRDARGF
     FGPMVNLMLF HSELKFGSLM GSINVLSTGP VEDLSINLYN GLGNRIHIDF EANPRLYGDA
     ELSMHHGRFL DYLSRFVGAA PQTVIADMPV LTDLERERVL HEWNSTQVAR QEGTLAGLFA
     DRAAMSAGRI ALDYEGETLT YAAFDERANR LARELVSRGV GPDTLIGLAV RRSLDLLIGM
     YAIVKAGAAY LPIDPDHPAD RIEAILEQAR PLCVLTTVRD RLELPRTAPR FDIDTADLSR
     HSGRPVTDAD RRAPLRADHL AYVIFTSGST GKPKGVGVTH AAIVNRLRWM QHAYPLDGSD
     VVLQKTPATF DVSVWEFFWP LQIGARLVIA APDGHRDPGY LARVIAEQGV TTAHFVPSML
     SVFLTDTDVA GCTGLTRVFC SGEALPAATV AEFHAALGAG PEAPQLHNLY GPTEAAVDVT
     SWHCVPGTTE VPIGAPIWNT RTYVLDARLQ PVAPGVVGEL YLAGVQLARG YLGRAALTAD
     RFVANPFTPG TRMYRTGDLV RWRGSGRSGV LEYLGRSDFQ VKVRGLRIEL GEIEAALLAE
     ERVARAVCVA RRGRGGDELI AYVVGAPGAE SFGPAQPLDT AELTAALRRT LPSYMVPSFL
     MVLDELPLSA NGKVDRKALP EPDAGARRPA RPAAAPSNAV ERQLTGIFAE VLGTDEFDVE
     DSFFDLGGNS LTAARAVARV NAALGAALTI RDLFETSTVT ALATRLSDSR PEHASPKLVA
     GPRPQHIPLS LAQQRLWILN RFAEHAAAYN MPLAVKLTGP LDIPALRAGL VDVLERHESL
     RTTFPDTPDG PCQLVHPAAE IPLTLDPIDA THADVHALAS EFAGYSFDLR SQAPVRVALY
     ATGPDAYVFL MVLHHISGDG WSIAPLIRDI MTAVAARAGG HAPAWTPMPV QYADFALWQR
     ELLGDEADPA SALARQLAYW RAALADLPDQ LDLPLDRPRP RQRSTDGGTV AFTIPSDTRR
     ALAAVAAERG VSTFMVLHAA LATVLARLCN TTDIAIGTPI AGRSDPALDD LVGMFVNTLV
     LRTRVDPAAG FDRMLTEVRD TDLNAFANAD VPFERLVEVV NPERSAARHP LFQVMLSYDG
     SPELRVDLPG VDTEVLPMAD DVAKFDLQLT VHEPAGGPAD GAPLTAEFGY AADVFDRATV
     EAIARRFGVV LAAAVADPSL PVGDLPLLDA RETAKLVPIM GSPAEPAISL ARLLADTAER
     VPDAVAVRYL GADTTYRELD ERSNRLARVL IEHGAGPEVV VAIALPRGHD SILAVWSVAK
     TGAAYVPIDP DYPSDRIAHM LADSGAMLGI TDAERRAELP DWPGSRGRHR KSYVDWLLLG
     SDQLAEECAQ FPDTAVTDAD RHHPLRTGGP AYLIYTSGST GRPKAVVVTN AGLSSLAHEQ
     MHLFKVTDSA RTLHFSSPSF DASVLELLLG FAAGATIVVV PAGIFGGIEL ARILREEKVT
     HAFVTPAALG TVPADDLPDL EAVIVGGEAC PEELVTVWTA PESRPGLPAR RMHNMYGPSE
     ATVAATATGP MVAGQPVPIG GPVRGMRLFV LDGRLHPVPP GVAGELYLSG PGLARGYLGR
     HDLTAQRFPA NPHGRRGERM YRTGDLVVAD GTGQLRFLGR ADDQIKIRGF RIELREIDHV
     LAAHPGVTFA LTVVHHDERG IPRLVAYLTA DTELEPAAVL EAARGRLPGY MVPSALSILD
     AMPVTPSGKL DRKALPAPEF VAAAPTRAPE TELEQQVALV FGAVLGATVP GADDNFFEIG
     GNSLLATRLT ASLHTEFGVE LPVRAIFEAP TVAGLAARLA EAPRTQRIAL AVHSPRPERV
     PLSLPQQRLW FLNRYSPESS AYNIAFVLRI DGDPDIDALR AALADVVERH EVLRTVFPED
     EHGAYQVVLD TARCLPVLEP VETDDVGART ALRSLARRGF DLTREIPLRM TLLRTGNRRH
     LLGIALHHIA ADGWSLAPLT RDLAIAYTAR HGDAAPTWAP LPVQYADFSL WQRDLLGADT
     DADSAAAAQL AYWRHALADL PEELPLPYDR TRPAEPTGRA GTVRFEVPEA LQRKLADVAR
     AHGVSLFMVL RSTLAVLLRA VTGGRDVVIG TPVAGRTDTR LDDLVGMFVN TLILRSDVDP
     DRSFAELLQA DRDTELAAMA HAEVPYERVV EELQTADGEE RQRRYGARPL LQVALTVQDT
     PVPALRLPGL SLHAEELDIA LAKFDLELRV LPGPDNGDDR VFEFVYAAEL FDQTTVDTLA
     ERMLRVFAAV AADPRVRVRD IDARTELERE MFTPAWGPAP EPQCSLAAYC AATAHLNADR
     VFLRFDDTEL TYLESDVYSN RLARALIHRG LGPGDRVALG LTRSVESVLA VLAVAKCGAA
     FVPVDPNYPA DRVRHMLVDS GCRVGISMTE HSADLHTAAG DHPVDWLLLD NAELLDELEV
     LDDGTLTDAE RATTLWTADL AYVIYTSGST GKPKGVAVTH GGLSNFADEI RERMRVDRDS
     RTMHFSSPSF DAAIFDLLLA VGAGATMIIV PPDVYGGDEL AALMDREEVS HTFMTPAALA
     TIDRERWALP HLRSVMVGGE ACGPELVARW APGRMMFNGY GPTETTVVVT IAGPLAVGAP
     ITIGTLVRGA RALVLDERLR PVPVGVPGEL YIGGQGCARG YFERLDLTAS RFVADPYGPE
     GSRLYRTGDV VRWTTGGEIA YLGRSDHQVK VRGFRIELGE IDGVLTAHRA IRFAHTEVRE
     IAGARRIVSY VLPLDPAAAP DLEELRAHCA TELPAHMVPS AITLLDRIPL TPVGKLDRDA
     LPQPQAVVAV VSRDPETDTE RLVAEVMGEL VGAEALGADD SFFEVGGNSL LATQLVARLA
     TATGVRLEVR TVFAAPTVAG LAAALDAGSA SADLRPEPRK RTRPARIPLS AAQRRLWFLE
     QFNASGDHGE ALGAYNVPVA LRLHGELDIP ALRAALHEVQ RRHETLRTVF PEIDGEPCQQ
     ILEPGEAAVT LPLRTVPESA VPEEIRRVTA SGFDLATCVP LRAALLRITG SKTEHVLVLV
     VHHIAMDGWS LQPLAADVAA AYRAHSGKAG RDGGAAGRDG KASGRDGKAP GRDGKAQSPE
     WPELPIQYAD YTLWQQDVLG REDDPESVIS RQLDYWRRAL DGIPELLAVP ADRPRPPVPS
     YRGGTVECTL DPFTHRELQN LAAEHGVTMF MVLHAALVAL LHRLTSGDDI TVGTPIAGRG
     HPALDRMVGM FVGTLVLRTH LDGGAAFADL LRAVRDTDLE AFAHADVPFE RLVEVLNPVR
     SQAHHPMFQV MLSVQHQPVR VLELPGMRIE ADDADPGIAK FDLQFTLTES WTGKREPDGI
     TVSVNYAADL FDEATAARLA QRFVRLLGAA AANPATAVGD LELLDSGEWS ALAPVRGTEP
     GLPITFPEVF EAAANLNRSA IAVRSAGTQI SYDALDRWTN RLARVLIGYG VGPETLVAMG
     IPRSAESVAV MLAIAKAGAA FVPVDPNYPE QRISHMLLDS GAAVGITLSS YRERMPDGAN
     WTVLDAPSFR RRVLATSDAP ISDTERTTSL RMDNPAYVIY TSGSTGIPKG VVVTHGGLSN
     FAAETAHRFD VGPGCRVLHF ATPSFDAAML DLLLALGGAA TLVITPPGVV GGQELGQVFI
     EEGITHAFIT TSALGTVDPT GVTALRHVLV GGEALPPDLV TRWAPGRKLY NVYGPTETTI
     VTVISQPMTP GGQITIGGPI RGVGATVLDA RLQPAPGGVT GELHLAGAAL ARGYLRRPGM
     TAQRFVANPF GKPGERMYRT GYLVRWLERG GRARDLEYVG RTDHQVKIRG FRIELGEIDA
     ALAKHPAVEF ATTIGHRTPA GSTALVSYVK PRNGSAPTTA ELTAHVADLV PNYMVPQSIM
     LLDRVPLSPV GKLDRKALPE PVFAAREGYR APETPIEEAL CAAFAEVLGI EQVGADDGFF
     ELGGNSLLAT KVVAQLRAAG VDLPVQAMFG DSTPAAIAAR LAAADGDAGA ALAAALGAVL
     PLRPVTADSS VPPLFCVHPA IGLSWCFAGL LSHLPHERPV YGLQAPHVAG EESHRTIAEA
     AKYYVAHMKS VQPHGPYHVL GWSLGGLLAH EVAVQLQQGG DEVALLALMD SYQLSDRWLE
     AAVPSVSAII AEFGSDLLGG DADIDPRMTL HEAAELLRSR SGPFAALTVE HLERLYTGYE
     NGAQQAHGFQ PHVFDGDLLF FTAADDEINR ADPDRCAAAW EPYVTGVVHD QLVRCTHAGM
     TTPESLAVIG PVLRDRLAAI DARREGTA
//