ID A0A0B8NP52_9NOCA Unreviewed; 287 AA.
AC A0A0B8NP52;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:APA97861.1};
DE EC=1.1.1.31 {ECO:0000313|EMBL:APA97861.1};
DE SubName: Full=Oxidoreductase {ECO:0000313|EMBL:GAM49963.1};
GN ORFNames=NS07_v2contig00130-0017 {ECO:0000313|EMBL:GAM49963.1},
GN NS506_03812 {ECO:0000313|EMBL:APA97861.1};
OS Nocardia seriolae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=37332 {ECO:0000313|EMBL:GAM49963.1, ECO:0000313|Proteomes:UP000019401};
RN [1] {ECO:0000313|EMBL:GAM49963.1, ECO:0000313|Proteomes:UP000019401}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N-2927 {ECO:0000313|EMBL:GAM49963.1,
RC ECO:0000313|Proteomes:UP000019401};
RA Imajoh M., Fukumoto Y., Yamane J., Sukeda M., Shimizu M., Ohnishi K.,
RA Oshima S.;
RT "Draft Genome Sequence of Nocardia seriolae Strain N-2927 (NBRC 110360),
RT Isolated as the Causal Agent of Nocardiosis of Yellowtail (Seriola
RT quinqueradiata) in Kochi Prefecture, Japan.";
RL Genome Announc. 3:e00082-15(2015).
RN [2] {ECO:0000313|EMBL:APA97861.1, ECO:0000313|Proteomes:UP000180166}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EM150506 {ECO:0000313|EMBL:APA97861.1,
RC ECO:0000313|Proteomes:UP000180166};
RA Han H.-J.;
RT "Genome sequence of Nocardia seriolae strain EM150506, isolated from
RT Anguila japonica.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; CP017839; APA97861.1; -; Genomic_DNA.
DR EMBL; BAWD02000130; GAM49963.1; -; Genomic_DNA.
DR RefSeq; WP_033090732.1; NZ_WMKH01000174.1.
DR STRING; 37332.NS506_03812; -.
DR GeneID; 61149509; -.
DR KEGG; nsr:NS506_03812; -.
DR PATRIC; fig|37332.12.peg.3919; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000019401; Unassembled WGS sequence.
DR Proteomes; UP000180166; Chromosome.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:APA97861.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019401}.
FT DOMAIN 3..156
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..282
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 287 AA; 29797 MW; 0FA85B7AD786493C CRC64;
MGEVAVIGLG GMGRAIARNL ARAGHEVVVW NRSAGPAAEL AEEGALRVAN VAEALRCPVV
FSVLADDTAF AEVFLDSGVL GAAEQGMVHV NMATVSVALA RRAVAAHAAH GSGYVAAPVF
GRVPVAEAGA LNILAAGEPR FIDRVQPFFD VIGSRTWRLG EQPEKADVAK ILGNYLIACT
IQSLGESISV ADAAGVDPSQ FVELLSATLF PGPVYSGYGS MIAERKYQPA AFTTALGRKD
LHLALEVATA EAIPLPFGEL LSGVFDQAIT AGHAADDWAA IAEQQPR
//
