ID   A0A0B8NSA8_9VIBR        Unreviewed;       669 AA.
AC   A0A0B8NSA8;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Protease, insulinase {ECO:0000313|EMBL:GAM55197.1};
GN   ORFNames=JCM19231_470 {ECO:0000313|EMBL:GAM55197.1};
OS   Vibrio ishigakensis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=1481914 {ECO:0000313|EMBL:GAM55197.1, ECO:0000313|Proteomes:UP000031671};
RN   [1] {ECO:0000313|EMBL:GAM55197.1, ECO:0000313|Proteomes:UP000031671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 19231 {ECO:0000313|Proteomes:UP000031671};
RA   Sawabe T., Meirelles P., Feng G., Sayaka M., Hattori M., Ohkuma M.;
RT   "Vibrio sp. C1 JCM 19231 whole genome shotgun sequence.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:GAM55197.1, ECO:0000313|Proteomes:UP000031671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 19231 {ECO:0000313|Proteomes:UP000031671};
RG   NBRP consortium;
RA   Sawabe T., Meirelles P., Feng G., Sayaka M., Hattori M., Ohkuma M.;
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAM55197.1}.
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DR   EMBL; BBRZ01000011; GAM55197.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B8NSA8; -.
DR   Proteomes; UP000031671; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 3.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR11851:SF149; GH01077P; 1.
DR   PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 3.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:GAM55197.1};
KW   Protease {ECO:0000313|EMBL:GAM55197.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031671}.
FT   DOMAIN          5..106
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          255..363
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          404..576
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   669 AA;  74265 MW;  CAE8443A14CB6F14 CRC64;
     MTTEDRIQQP MLLIGWPTTY QGAEGNENID MLARVLGSGR NSILYQKLVK TEKALDAGAF
     HQCAELACNF FVYVMADSSK RADLSPLYDE VMGILDGLKP EDIDPDFLKQ VQGRAEADSV
     FALQSVRGKV TQLASNQTFY GQPDRLQTEL DKLGKVTPDS VYKAYQTYIP NKHKVALSVV
     PRGKLELAAR EATFDTPPRN LPEQKPILDS ELDYRFVEDT FDRSKVPEAQ GAVRGTMPEL
     YSFHLDNDIE VLGTQTSETP TVVMQIKMPA GNRYVPRGKE GLAALTASMV SEGGTRLSSE
     ELQAELDKLG SSASLDAGQY RSTVTISSLS KNFVPTLKLV EEALSSPKFD PQDFERVKRQ
     MLEGVIYEHQ TPSWLASQAT RQVLYGNTVY GRSSSGTIES VKGLTLDDVK NFYKQYYTPK
     GTQVVIVGDL EQAKVRDSLD SLASWQGDMP PILRKQRLPQ QEERSIYLVD KPGAPQSTVR
     LVRRGLPFDA TGEMYLTQLA NFNLGGNFNS RINQNLREDK GYTYGASTYI AANREVGALV
     ATAQVRADST GDALVELIKE MEGAAQDGFT DQEIEFMRLA VGQQDALKYE TPGQKASLLG
     AILTYNLDYD YLSTRNDIVA NVSKQSLNEV ANKWFNPDDY QIVVVGDAEK ITPQLQKLKL
     PIKTLEIEP
//