ID A0A0B9A6X2_BRELN Unreviewed; 325 AA.
AC A0A0B9A6X2; A0A144MLP2;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=2-oxoisovalerate dehydrogenase {ECO:0000313|EMBL:AMT95189.1};
DE SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) {ECO:0000313|EMBL:KHS51143.1};
DE EC=1.2.4.1 {ECO:0000313|EMBL:KHS51143.1};
GN ORFNames=A2T55_16970 {ECO:0000313|EMBL:AMT95189.1}, AE0388_3215
GN {ECO:0000313|EMBL:KHS51143.1};
OS Brevibacterium linens.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Brevibacteriaceae;
OC Brevibacterium.
OX NCBI_TaxID=1703 {ECO:0000313|EMBL:KHS51143.1, ECO:0000313|Proteomes:UP000031488};
RN [1] {ECO:0000313|EMBL:KHS51143.1, ECO:0000313|Proteomes:UP000031488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AE038-8 {ECO:0000313|EMBL:KHS51143.1,
RC ECO:0000313|Proteomes:UP000031488};
RA Maizel D., Utturkar S.M., Brown S.D., Ferrero M., Rosen B.P.;
RT "Draft Genome Sequence of Brevibacterium linens AE038-8.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000075950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BS258 {ECO:0000313|Proteomes:UP000075950};
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AMT95189.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BS258 {ECO:0000313|EMBL:AMT95189.1};
RA Zhu Y., Sun C.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP014869; AMT95189.1; -; Genomic_DNA.
DR EMBL; JTJZ01000022; KHS51143.1; -; Genomic_DNA.
DR RefSeq; WP_039211925.1; NZ_JTJZ01000022.1.
DR STRING; 1703.BLSMQ_3683; -.
DR KEGG; bly:A2T55_16970; -.
DR PATRIC; fig|1703.6.peg.3172; -.
DR OrthoDB; 3457658at2; -.
DR Proteomes; UP000031488; Unassembled WGS sequence.
DR Proteomes; UP000075950; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:KHS51143.1};
KW Pyruvate {ECO:0000313|EMBL:KHS51143.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031488}.
FT DOMAIN 4..179
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 325 AA; 35636 MW; B708814627BE5D88 CRC64;
MEKLPLSKAI TAGMRKAMED DPKVVLIGED IGKLGGVFRV TEGLQKDFGP QRVIDAPLAE
SGIVGTSIGM AIRGYRPVIE IQFDAFIFPA YDQIVTQVAK LYNRTLGKEN IPLVIRVPYG
GGIGSPEHHS ESPETVFAHH AGLRLVSPAN AHDAYWMIQD AIKSADPVMF FEPKRRYWMR
GDVDTSARGE LGMHDARVVS EGTDVTLVAY GPLVPTAQDV VTAAAEEGKS VELIDLRSLN
PIDFTTIEKS VTKTGRLVVA HEAPTFLGLG SEIAARITER CFFNLEAPVI RVGGYHTPYP
GSRMEEHYLP DLDRIFDGVD RALSY
//
