ID A0A0B9ANA2_BRELN Unreviewed; 285 AA.
AC A0A0B9ANA2; A0A144M3I1;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:KHS50825.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:KHS50825.1};
GN ORFNames=A2T55_01455 {ECO:0000313|EMBL:AMT92628.1}, AE0388_2897
GN {ECO:0000313|EMBL:KHS50825.1};
OS Brevibacterium linens.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Brevibacteriaceae;
OC Brevibacterium.
OX NCBI_TaxID=1703 {ECO:0000313|EMBL:KHS50825.1, ECO:0000313|Proteomes:UP000031488};
RN [1] {ECO:0000313|EMBL:KHS50825.1, ECO:0000313|Proteomes:UP000031488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AE038-8 {ECO:0000313|EMBL:KHS50825.1,
RC ECO:0000313|Proteomes:UP000031488};
RA Maizel D., Utturkar S.M., Brown S.D., Ferrero M., Rosen B.P.;
RT "Draft Genome Sequence of Brevibacterium linens AE038-8.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AMT92628.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BS258 {ECO:0000313|EMBL:AMT92628.1};
RA Zhu Y., Sun C.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000075950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BS258 {ECO:0000313|Proteomes:UP000075950};
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
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DR EMBL; CP014869; AMT92628.1; -; Genomic_DNA.
DR EMBL; JTJZ01000022; KHS50825.1; -; Genomic_DNA.
DR RefSeq; WP_039211566.1; NZ_JTJZ01000022.1.
DR STRING; 1703.BLSMQ_0153; -.
DR KEGG; bly:A2T55_01455; -.
DR PATRIC; fig|1703.6.peg.2844; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000031488; Unassembled WGS sequence.
DR Proteomes; UP000075950; Chromosome.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KHS50825.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031488}.
FT DOMAIN 18..187
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 190..285
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT BINDING 61
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-3"
FT BINDING 68
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-3"
FT BINDING 123
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-3"
FT SITE 144
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 285 AA; 29809 MW; 4469AC499AA98885 CRC64;
MSDTTRSTPN SARVPDVVGV YGGGRMGAGI AHAFATAGAR VIVIENTDET VAAARERIDA
SIEKSQSKGI EVPGTVVVDR DPTLLDEALL VVEAVPEIVE LKQEVLATIA KHAPAASIGT
NTSALSIDEL AAALPRPQAL IGLHFFNPVP VSELVEVVVG THTDPKLVDV AKEWVTGLGK
TAITVKDSPG FASSRLGVAL ALEAMRMVED GVASASDIDR AMTLGYRHPA GPLKTTDIVG
LDVRLGIAEH LAAEIGERFA PPQILKDKVA AGELGRKTGQ GFYTW
//
