ID A0A0C1YJM8_9CYAN Unreviewed; 882 AA.
AC A0A0C1YJM8;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN Name=adhE {ECO:0000313|EMBL:NEV69491.1};
GN Synonyms=adhC {ECO:0000313|EMBL:NEV69491.1};
GN ORFNames=QQ91_020550 {ECO:0000313|EMBL:NEV69491.1};
OS Lyngbya confervoides BDU141951.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Oscillatoriaceae; Lyngbya.
OX NCBI_TaxID=1574623 {ECO:0000313|EMBL:NEV69491.1, ECO:0000313|Proteomes:UP000031561};
RN [1] {ECO:0000313|EMBL:NEV69491.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BDU141951 {ECO:0000313|EMBL:NEV69491.1};
RA Malar M.C., Sen D., Tripathy S.;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:NEV69491.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BDU141951 {ECO:0000313|EMBL:NEV69491.1};
RX PubMed=25745003;
RA Chandrababunaidu M.M., Sen D., Tripathy S.;
RT "Draft Genome Sequence of Filamentous Marine Cyanobacterium Lyngbya
RT confervoides Strain BDU141951.";
RL Genome Announc. 3:e00066-e00015(2015).
RN [3] {ECO:0000313|EMBL:NEV69491.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BDU141951 {ECO:0000313|EMBL:NEV69491.1};
RA Sarangi A.N., Ghosh S., Mukherjee M., Tripathy S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NEV69491.1}.
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DR EMBL; JTHE02000003; NEV69491.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C1YJM8; -.
DR Proteomes; UP000031561; Unassembled WGS sequence.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR CDD; cd08178; AAD_C; 1.
DR CDD; cd07122; ALDH_F20_ACDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR034789; AAD_C.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012079; Bifunc_Ald-ADH.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR PIRSF; PIRSF000111; ALDH_ADH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00913; ADH_IRON_1; 1.
DR PROSITE; PS00060; ADH_IRON_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000111}.
FT DOMAIN 7..399
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 456..846
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 882 AA; 96444 MW; 12DABAF321615E95 CRC64;
MTVNSLETLE TLVDRVKAAQ AEYATFTQAQ VDRIFHQAAL AANTKRIPLA KQAVQETGMG
IVEDKVIKNH FASEMVYNKY KDEKTCGLIE NEPGYGLQKI AEPVGILAGI VPTTNPTSTA
VFKALLALKT RNGIIFSPHP RAKGCTKEAA KIVRDAAVAA GAPADIIGWI DEPTVELSQA
LMSHPDIKLI LATGGPGMVK AAYSSGNPSL GVGAGNTPAV IDSTAHIKMA VNSVLISKSF
DNGMICASEQ SVVVVDEVYD EVRAEFIERG AYLLNDDEKD KVRQIILKNG RLNAAIVGQS
TAQLAELAGI TVPEGTRVLI GEVSDINTEE PFAYEKLSPI LAMYRAPDFG HAVEMAAALI
RFGGMGHTSV LYTNPAQHDH IQHFEEQMTT ARVLINTPSS QGAIGDLYNF KLDPSLTLGC
GSWGGNSVSG NVGPQHLLNI KTVTERRENM LWFRIPPKVY FKFGCLATAL KDIQGRQRAF
IVTDKPLFDL GMCDRVTQVL EDMGLRYEVF HDVEPDPSLD TVMRGVDAMN KFEPDVIIPV
GGGSPMDAAK IMWLMYEHPE TDFESLAMRF MDIRKRVYEL PPLGDRAILV AIPTTSGTGS
EVTPFAVVTD NRTGMKYPLA DYALTPHIAI IDPELVLHMP KALTAYGGLD ALTHAIEAYV
SVLASEFTNG QALEAIRLIF KYLPSAYENG AKDPKAREKV HYAATMAGMA FANAFLGVCH
SLAHKLGSTF HVPHGLANAL LISHVIRYNA TDAPFKQAIF PQYKYPNAKY RYARIADHLG
LGGDTEEEKV ELLIAAIEDL KHRLNIPDSI HDVIPEVDKR FYAEVEEMAE NAFDDQCTGA
NPRYPMIKEL KELYLLAHRG CRIDAAMYNQ DDSEAIQEAV NA
//
