ID   A0A0C2CU28_9BILA        Unreviewed;       705 AA.
AC   A0A0C2CU28;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=DNA mismatch repair protein {ECO:0000313|EMBL:KIH60383.1};
GN   ORFNames=ANCDUO_09368 {ECO:0000313|EMBL:KIH60383.1};
OS   Ancylostoma duodenale.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=51022 {ECO:0000313|EMBL:KIH60383.1, ECO:0000313|Proteomes:UP000054047};
RN   [1] {ECO:0000313|EMBL:KIH60383.1, ECO:0000313|Proteomes:UP000054047}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zhejiang {ECO:0000313|EMBL:KIH60383.1,
RC   ECO:0000313|Proteomes:UP000054047};
RA   Mitreva M.;
RT   "Draft genome of the parsitic nematode Ancylostoma duodenale.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KN731012; KIH60383.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C2CU28; -.
DR   Proteomes; UP000054047; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd00782; MutL_Trans; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR032189; Mlh1_C.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF16413; Mlh1_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054047}.
FT   DOMAIN          211..338
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   REGION          369..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   705 AA;  78736 MW;  7B276CB4FA7CA214 CRC64;
     MLSSQFFYEE DHNSWKYYVV VRPANAVKEL IENSLDAGAT EIIVTVKDGG LSLLQVQDNG
     KGIQKDDLDI VCERFTTSKL NRYEDLQSMR TYGFRGEALS SISHVAKVTI TSKPAGQQCA
     YQAKYIGTDG KPESIKASAG LDGTCIAAED LFYNCPNRKK AFRHHADEAN KVTDVVMRYA
     VHRPDVSFAM RRGGTGADFR TSGRCSRAEI ITSLLGKDCG GDMIEFTHTS QRLHYSCDVC
     LTPPVSSVTA RSVQAKKKHQ RSFFIFINGR LVQCQNLKFA VDTLFSDRDL VCPFALVSLT
     IDSSRIDVNV HPTKQKVVFL EEEAIIEELA KEIEMKLANV FDREVAPRSI SKQQQSLLTS
     TQILRIPGQT QASSPLGPLR DVSDGDVSQP RSPAVPKKRV DYELVRVDKK ERRLDEFISN
     TKTAQSSSSV EIVQVAGSQH EDSVHNETAD DKGRRVFQFE SLNNLRRKIC DGASQPLREL
     FKSLIFVGCV SPNTMLLQFG TGLYIIQLRD VLKELFYQTL IFSFGNFGSF KLAEDGANVS
     ELLQLAGLES EHELAALELL ESQAEMLNDY FSLRIARPDG TEQDADGLRQ LAVVTLPSII
     DGYTPQMEGL PALMMSLVKD VEWEEEEACF DSVCRALAEF FVIKEEFCDG DNISGLEGGR
     APWRTVIRDL LVPRVKSHLV PPDSLRDGTS RLADLHDLYK VFERC
//