ID   A0A0C2H441_9BILA        Unreviewed;      1196 AA.
AC   A0A0C2H441;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:KIH68600.1};
GN   ORFNames=ANCDUO_01066 {ECO:0000313|EMBL:KIH68600.1};
OS   Ancylostoma duodenale.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=51022 {ECO:0000313|EMBL:KIH68600.1, ECO:0000313|Proteomes:UP000054047};
RN   [1] {ECO:0000313|EMBL:KIH68600.1, ECO:0000313|Proteomes:UP000054047}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zhejiang {ECO:0000313|EMBL:KIH68600.1,
RC   ECO:0000313|Proteomes:UP000054047};
RA   Mitreva M.;
RT   "Draft genome of the parsitic nematode Ancylostoma duodenale.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; KN726337; KIH68600.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C2H441; -.
DR   Proteomes; UP000054047; Unassembled WGS sequence.
DR   GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10676:SF352; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR   PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054047}.
FT   DOMAIN          190..262
FT                   /note="Dynein heavy chain AAA module D4"
FT                   /evidence="ECO:0000259|Pfam:PF12780"
FT   DOMAIN          239..527
FT                   /note="Dynein heavy chain coiled coil stalk"
FT                   /evidence="ECO:0000259|Pfam:PF12777"
FT   DOMAIN          546..763
FT                   /note="Dynein heavy chain ATP-binding dynein motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12781"
FT   DOMAIN          969..1079
FT                   /note="Dynein heavy chain region D6 P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF03028"
FT   COILED          247..274
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          400..459
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1196 AA;  134753 MW;  E9FBA9A3DD1ECB8D CRC64;
     MICSSASAIL QCLSQHCVQT SSASGRVLRP KDRAQLILYL KSLNLPAPDK ITASMAPSTT
     HSSIPPRLVS QMRMLAIGYP SEQNLNAIYC AYLMPILEPP LGSSTRVEAM ASAMVRLYEE
     IRSNFRPADR GHYIFTPRDL TKWTLGIMRH ELSDDQRYPM LLVLMCVNAI PIGYDFIRRA
     PSKTARTINL LQVIQSAISN SEHVVLLIED YEILRSSFLE AINCLISSGE VPGLLAPQGA
     EDQKTSMEKL RTATEEENAK IAEKKKKIDE QLKDVEPLLK EARSAVGSIK SESLSEIRSL
     RAPPEAIRDI LQAVLLFMGI LDTSWEAMRK FLSKSSVKDE IINFDAHRIT RDVHKKVSAL
     VKSKEASFDP KNAKRASVAA APLAAWVTAN LQYSEILEKI SPLEQEKNEL VSNLSKAEKQ
     IQKLSKGLLT VDEKVAALKE KFEMLMKEAT QIKIDLEKEQ DTIKVAGTLI DRLGGEFTRW
     QAQMESLSKE MDNVERCALV TATFVTYLGG CSEHTRTEVL KSFRQNYNLQ DFSPVTFCAT
     ETEQLNWKNH GLPADSLSIE NTVIMLNSTQ TPMVIDPTGR VAAFLHSFHP KAELLRATQN
     DLFTQIEFGI RFGKTIIVDD VTEVDAVLVP IFRKELSSQG PRQVISFADK QIDFHPDFKL
     FLCTKNQHIV IPSSIRNVLS EVNFTTTRSG LTSQLLGLAI QIEKPELEER SSALARDAEG
     KKMELEKLEQ LLLQQLASSE ENLLGNTVLL DSLNKSKQNA ETISRGIEES EKLRKELNDV
     KRIPKPNTGT YRCFQDNTSS RIDTQMRSLQ LAVFYYISRA LFKVDRLMFA LSFVHGTLPK
     MFLPKEWELF TGFILDEQQV SPVAIPWVDE SRYSAVAKLQ AHLPTLYNNL QFSDQGTWNE
     FSRAVDCENT IPSAIETKIT PFQKVLLIQA VRPDRLYAAM QNFVLKTLSL PSINPPPFDL
     ADILAESSNQ EPILLILAGG ADPSQELEEL AAKTIGYHNY VSISMGQGQE QATIDGIRKA
     TKEGQWICLY NVHLMLSIIP TIQKELAAAT PHERFRLWMT TEEESKFPAM MLQRSLKVTF
     EPPPGIRNNL LRTYSQIDDA RRSVLTTQAT FVLAWLHALL QERRTFIPQM FHFTKIKFSS
     RHGNLEARFQ VQKVHACLSL ISKSIRGTVT PDKSTLEVIK SLQLHQVGLR NRLTLF
//