ID   A0A0C2JHG4_9ACTN        Unreviewed;       404 AA.
AC   A0A0C2JHG4;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=ROK family transcriptional regulator {ECO:0000313|EMBL:KIH96442.1};
GN   ORFNames=LP52_24925 {ECO:0000313|EMBL:KIH96442.1};
OS   Streptomonospora alba.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Nocardiopsaceae; Streptomonospora.
OX   NCBI_TaxID=183763 {ECO:0000313|EMBL:KIH96442.1, ECO:0000313|Proteomes:UP000031675};
RN   [1] {ECO:0000313|Proteomes:UP000031675}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM 90003 {ECO:0000313|Proteomes:UP000031675};
RX   PubMed=25601074; DOI=10.1016/j.chembiol.2014.11.017;
RA   Metelev M., Tietz J.I., Melby J.O., Blair P.M., Zhu L., Livnat I.,
RA   Severinov K., Mitchell D.A.;
RT   "Structure, bioactivity, and resistance mechanism of streptomonomicin, an
RT   unusual lasso Peptide from an understudied halophilic actinomycete.";
RL   Chem. Biol. 22:241-250(2015).
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family.
CC       {ECO:0000256|ARBA:ARBA00006479}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KIH96442.1}.
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DR   EMBL; JROO01000067; KIH96442.1; -; Genomic_DNA.
DR   RefSeq; WP_040276860.1; NZ_JROO01000067.1.
DR   AlphaFoldDB; A0A0C2JHG4; -.
DR   STRING; 183763.LP52_24925; -.
DR   OrthoDB; 3523179at2; -.
DR   Proteomes; UP000031675; Unassembled WGS sequence.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 3.30.420.40; -; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR18964:SF149; BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE; 1.
DR   PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR   Pfam; PF12802; MarR_2; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000031675}.
FT   DOMAIN          18..68
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000259|Pfam:PF12802"
SQ   SEQUENCE   404 AA;  41798 MW;  B60D2950A9E616DF CRC64;
     MSRRPGTPRL LRQLNDRAAL ELLLASGPLT RTQLGQETGL SKVTASQLLA RLEERRLVHV
     VGSQAGGRGP NAALYAVVPS SAYALALDIR ASEVTGAIAD ITGQVTGEFT LDPTDTHNPV
     DQVSGAVMRL LSTCEVPLDH LSACTIGTPG VVDPRTGAVR FSFDLHSWLE DAFHTLRNDL
     GPIVRIENDV NLAARAEHAE GAGEDASDFA LIWLGGGGGV GMAVVLDDRI HWGTTGGAGE
     IGYLPVPGAP LPGDVGLPGG YQSLSRTGER PTIAHGFQAL VGAQEIVTLG ESHGFTGKTV
     GDVLTAAAEA RDAGEGFLDA LAERIARGVA AVCVVLDPGL VVLGGEVAES GGDDLAQRVA
     RATARIGPNA PQVSVGRVQS PVLRGALLSA LQHAREDVFE STVE
//