ID A0A0C4BJE5_WHEAT Unreviewed; 510 AA.
AC A0A0C4BJE5;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Serine hydroxymethyltransferase {ECO:0000256|RuleBase:RU000585};
DE EC=2.1.2.1 {ECO:0000256|RuleBase:RU000585};
GN ORFNames=CFC21_053242 {ECO:0000313|EMBL:KAF7043953.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4B02G069300.1};
RN [1] {ECO:0000313|EMBL:KAF7043953.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7043953.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4B02G069300.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4B02G069300.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4B02G069300.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7043953.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7043953.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Interconversion of serine and glycine.
CC {ECO:0000256|RuleBase:RU000585}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O =
CC (6S)-5,6,7,8-tetrahydrofolate + L-serine; Xref=Rhea:RHEA:15481,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15636, ChEBI:CHEBI:33384,
CC ChEBI:CHEBI:57305, ChEBI:CHEBI:57453; EC=2.1.2.1;
CC Evidence={ECO:0000256|RuleBase:RU000585};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR000412-50, ECO:0000256|RuleBase:RU000585};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU000585}.
CC -!- SIMILARITY: Belongs to the SHMT family. {ECO:0000256|ARBA:ARBA00006376,
CC ECO:0000256|RuleBase:RU000585}.
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DR EMBL; CM022220; KAF7043953.1; -; Genomic_DNA.
DR SMR; A0A0C4BJE5; -.
DR STRING; 4565.A0A0C4BJE5; -.
DR PaxDb; 4565-Traes_4AL_24F8F34EE-1; -.
DR EnsemblPlants; TraesCS4A02G246100.1; TraesCS4A02G246100.1; TraesCS4A02G246100.
DR EnsemblPlants; TraesCS4B02G069300.1; TraesCS4B02G069300.1; TraesCS4B02G069300.
DR EnsemblPlants; TraesCS4D02G068100.1; TraesCS4D02G068100.1; TraesCS4D02G068100.
DR Gramene; TraesCAD_scaffold_112839_01G000100.1; TraesCAD_scaffold_112839_01G000100.1; TraesCAD_scaffold_112839_01G000100.
DR Gramene; TraesCAD_scaffold_123728_01G000100.1; TraesCAD_scaffold_123728_01G000100.1; TraesCAD_scaffold_123728_01G000100.
DR Gramene; TraesCLE_scaffold_051657_01G000200.1; TraesCLE_scaffold_051657_01G000200.1; TraesCLE_scaffold_051657_01G000200.
DR Gramene; TraesCLE_scaffold_085479_01G000200.1; TraesCLE_scaffold_085479_01G000200.1; TraesCLE_scaffold_085479_01G000200.
DR Gramene; TraesCS4A02G246100.1; TraesCS4A02G246100.1; TraesCS4A02G246100.
DR Gramene; TraesCS4A03G0649400.1; TraesCS4A03G0649400.1.CDS; TraesCS4A03G0649400.
DR Gramene; TraesCS4B02G069300.1; TraesCS4B02G069300.1; TraesCS4B02G069300.
DR Gramene; TraesCS4D02G068100.1; TraesCS4D02G068100.1; TraesCS4D02G068100.
DR Gramene; TraesCS4D03G0128500.1; TraesCS4D03G0128500.1.CDS; TraesCS4D03G0128500.
DR Gramene; TraesKAR4A01G0340070.1; cds.TraesKAR4A01G0340070.1; TraesKAR4A01G0340070.
DR Gramene; TraesKAR4B01G0042420.1; cds.TraesKAR4B01G0042420.1; TraesKAR4B01G0042420.
DR Gramene; TraesKAR4D01G0033410.1; cds.TraesKAR4D01G0033410.1; TraesKAR4D01G0033410.
DR Gramene; TraesPAR_scaffold_088990_01G000200.1; TraesPAR_scaffold_088990_01G000200.1; TraesPAR_scaffold_088990_01G000200.
DR Gramene; TraesPAR_scaffold_114899_01G000100.1; TraesPAR_scaffold_114899_01G000100.1; TraesPAR_scaffold_114899_01G000100.
DR Gramene; TraesROB_scaffold_020754_01G000500.1; TraesROB_scaffold_020754_01G000500.1; TraesROB_scaffold_020754_01G000500.
DR Gramene; TraesROB_scaffold_026189_01G000200.1; TraesROB_scaffold_026189_01G000200.1; TraesROB_scaffold_026189_01G000200.
DR Gramene; TraesROB_scaffold_050685_01G000200.1; TraesROB_scaffold_050685_01G000200.1; TraesROB_scaffold_050685_01G000200.
DR Gramene; TraesWEE_scaffold_059586_01G000300.1; TraesWEE_scaffold_059586_01G000300.1; TraesWEE_scaffold_059586_01G000300.
DR Gramene; TraesWEE_scaffold_121403_01G000100.1; TraesWEE_scaffold_121403_01G000100.1; TraesWEE_scaffold_121403_01G000100.
DR eggNOG; KOG2467; Eukaryota.
DR HOGENOM; CLU_022477_0_1_1; -.
DR OMA; MINKYSE; -.
DR OrthoDB; 5358603at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000019116; Chromosome 4A.
DR Proteomes; UP000019116; Chromosome 4B.
DR Proteomes; UP000019116; Chromosome 4D.
DR Proteomes; UP000815260; Chromosome 4A.
DR ExpressionAtlas; A0A0C4BJE5; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IBA:GO_Central.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR GO; GO:0070905; F:serine binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0046655; P:folic acid metabolic process; IBA:GO_Central.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IBA:GO_Central.
DR GO; GO:0006565; P:L-serine catabolic process; IBA:GO_Central.
DR GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR GO; GO:0046653; P:tetrahydrofolate metabolic process; IBA:GO_Central.
DR CDD; cd00378; SHMT; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR HAMAP; MF_00051; SHMT; 1.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
DR InterPro; IPR039429; SHMT-like_dom.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF64; SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF00464; SHMT; 1.
DR PIRSF; PIRSF000412; SHMT; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00096; SHMT; 1.
PE 3: Inferred from homology;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563,
KW ECO:0000256|RuleBase:RU000585};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR000412-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000585}.
FT DOMAIN 48..445
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
FT MOD_RES 279
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR000412-50"
SQ SEQUENCE 510 AA; 56122 MW; D726BFAD700BBFA2 CRC64;
MAMATALRKL SARGQPLSRL TPLYSMASLP ATEERSAVTW PKQLNAPLEE VDPEIADIIE
LEKARQWKGL ELIPSENFTS LSVMQAVGSV MTNKYSEGYP GARYYGGNEY IDMAETLCQK
RALEAFNLDP EKWGVNVQPL SGSPANFHVY TALLKPHDRI MALDLPHGGH LSHGYQTDTK
KISAVSIFFE TMPYRLDEST GLIDYDQLEK SAVLFRPKLI VAGASAYARL YDYNRMRKIC
DKQKAVLLAD MAHISGLVAA GVIPSPFEYA DVVTTTTHKS LRGPRGAMIF FRKGVKEINK
QGKEVKYDFE DKINAAVFPG LQGGPHNHTI TGLAVALKQA TTQEYRAYQE QVMSNSARFA
ESLTSKGYDI VSGGTDNHLV LVNLKKKGID GSRVEKVLEN VHIAANKNTV PGDVSAMVPG
GIRMGTPALT SRGFVEEDFA KVADFFDSAV NLALKVKAAA AGTKLKDFVA TLQSDSNIQA
EIAKLRHDVE EYAKQFPTIG FEKETMKYKN
//
