ID A0A0C4YFW5_9BURK Unreviewed; 805 AA.
AC A0A0C4YFW5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Tyrosine-protein kinase Wzc {ECO:0000313|EMBL:AJG21615.1};
DE EC=2.7.10.2 {ECO:0000313|EMBL:AJG21615.1};
GN ORFNames=RR42_s0017 {ECO:0000313|EMBL:AJG21615.1};
OS Cupriavidus basilensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=68895 {ECO:0000313|EMBL:AJG21615.1, ECO:0000313|Proteomes:UP000031843};
RN [1] {ECO:0000313|EMBL:AJG21615.1, ECO:0000313|Proteomes:UP000031843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4G11 {ECO:0000313|EMBL:AJG21615.1};
RX PubMed=25977418;
RA Ray J., Waters R.J., Skerker J.M., Kuehl J.V., Price M.N., Huang J.,
RA Chakraborty R., Arkin A.P., Deutschbauer A.;
RT "Complete Genome Sequence of Cupriavidus basilensis 4G11, Isolated from the
RT Oak Ridge Field Research Center Site.";
RL Genome Announc. 3:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; CP010537; AJG21615.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C4YFW5; -.
DR STRING; 68895.RR42_s0017; -.
DR KEGG; cbw:RR42_s0017; -.
DR Proteomes; UP000031843; Chromosome secondary.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AJG21615.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000031843};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AJG21615.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..102
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 380..460
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 583..707
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 361..398
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 805 AA; 85754 MW; 245D3251023B9A3E CRC64;
MNRLSFAGAS PAANEPEQPR ARGSRALVDH LGWIVALTLA GGAIGALVAL SMPQHYRVEA
LVQVEPRDAG QNAGARGGAQ GGPAAPFDAG MLTSRAVVGP VVERLRLDVS AAPLRAPLVG
ALVARFAEPG QAMAAWPESL GYAWGGERIQ IDSLAVPERL LNVPLMLEVQ PQGHYRLYAG
NALLFEGVAG EPAAGNEVEL QVAKLDALPG TRFALVRHDP LSTMDAISRE LVVDEHTRDA
GTVRISWRYP DRKLAAALVN GVAQAYIDSQ TTQRRDDAAG SLAFVTGELP RVQGELERAE
AALTRYRTRS GTMAPTQDAQ SYLNGSMDYQ RQIAALRLER TRLLQRFTTD SNEVRTVDTQ
IQELSKVRRD MDSRMQNLSE TERESVALTR DVKVAEDMYM TLRNRVQQLS LVRSDRSNNM
RIVDAALAPA RPDGVGPWPL TGGGALLGLC LGLAGVAARQ RYRPSVGDAA DAEARLGMPM
LGEIAFSSEQ TELEHQSEVH RRLGMMMGFA AQPSPRLYAP APGSALAEPG GFSTGEAERL
LRCGLHDRFL LARRSPHALA VEGLRSVRAA LHFAVRNAPD AVLAVTSPAP GTGKTFACVN
LAVLFAEAGQ RVLLIDADLR RGKVANWFDQ AAEPGLAELL AGQAELAAVV RPTVVSGLSV
ITAGSMPPNP SELLMMPALA ETLQACKARF DLIIIDTPPV LAVADATLVA NLAGSTLLVV
RADVTPAAQV DETLKRLARA SARLAGGMLN GVTRRRSNRA DFAAMSPYLG LPLPAARPEA
LALESRPARH GTAEQQAGQG SMPAS
//
