ID A0A0C5FMP9_9ACTN Unreviewed; 443 AA.
AC A0A0C5FMP9;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=GntR family transcriptional regulator {ECO:0000313|EMBL:AJP01007.1};
GN ORFNames=TU94_05540 {ECO:0000313|EMBL:AJP01007.1};
OS Streptomyces cyaneogriseus subsp. noncyanogenus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=477245 {ECO:0000313|EMBL:AJP01007.1, ECO:0000313|Proteomes:UP000032234};
RN [1] {ECO:0000313|EMBL:AJP01007.1, ECO:0000313|Proteomes:UP000032234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NMWT 1 {ECO:0000313|EMBL:AJP01007.1,
RC ECO:0000313|Proteomes:UP000032234};
RA Wang H., Li C., Xiang W., Wang X.;
RT "Genome sequence of thermotolerant Streptomyces cyaneogriseus subsp.
RT Noncyanogenus NMWT1, the producer of nematocidal antibiotics nemadectin.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; CP010849; AJP01007.1; -; Genomic_DNA.
DR RefSeq; WP_044379848.1; NZ_CP010849.1.
DR AlphaFoldDB; A0A0C5FMP9; -.
DR STRING; 477245.TU94_05540; -.
DR KEGG; scw:TU94_05540; -.
DR PATRIC; fig|477245.3.peg.1212; -.
DR HOGENOM; CLU_017584_2_0_11; -.
DR OrthoDB; 4336542at2; -.
DR Proteomes; UP000032234; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000032234};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 9..77
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 443 AA; 46081 MW; F922C93A72669BF3 CRC64;
MLGEYRITGR GAAEISASVE RAVACGELEP GQPLPPMREL AERLGVNPNT VAAAYRTLRE
RGVIETAGRR GSRVRSTPAT TGREFIRVEV PEGARDVSAG NPDPALLPAL APAFAAAAGR
GDREPVLYGD APVEPELERL ARAELDADGV PGGPLAVTSG SLDAMERVLA AHLKPGDPVA
VEDPGWGSLL DLVPALGLRT VPVGVDDDGP LVDDVRRALA GGVRALVVTD RAQNPTGAAV
SAARARALRS LLREHPETLL IEDDHGHRIV DLPLHPLAGA TRSWAFVRSA AKAYGPDLRL
AVLTGDSVTL DRVRGRQRLG PGWVSRITQR AVARLWAEGA VDARAVAAAY GRRREALIGA
LAERGVTAHG RSGLNVWIPV PDETGAVARL LHAGWAVAPG ARFRLHAPPG IRITVSTLGA
GEAGPLADAV ASALGAGAGR SHV
//
