ID   A0A0C5FNA7_9ACTN        Unreviewed;       324 AA.
AC   A0A0C5FNA7;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=DNA polymerase {ECO:0000313|EMBL:AJP01317.1};
GN   ORFNames=TU94_07325 {ECO:0000313|EMBL:AJP01317.1};
OS   Streptomyces cyaneogriseus subsp. noncyanogenus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=477245 {ECO:0000313|EMBL:AJP01317.1, ECO:0000313|Proteomes:UP000032234};
RN   [1] {ECO:0000313|EMBL:AJP01317.1, ECO:0000313|Proteomes:UP000032234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NMWT 1 {ECO:0000313|EMBL:AJP01317.1,
RC   ECO:0000313|Proteomes:UP000032234};
RA   Wang H., Li C., Xiang W., Wang X.;
RT   "Genome sequence of thermotolerant Streptomyces cyaneogriseus subsp.
RT   Noncyanogenus NMWT1, the producer of nematocidal antibiotics nemadectin.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC       untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC       forks, which arise in vivo from mismatched or misaligned primer ends.
CC       These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC       exonuclease (proofreading) activity. May be involved in translesional
CC       synthesis, in conjunction with the beta clamp from PolIII.
CC       {ECO:0000256|ARBA:ARBA00025589}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC       {ECO:0000256|ARBA:ARBA00010945}.
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DR   EMBL; CP010849; AJP01317.1; -; Genomic_DNA.
DR   RefSeq; WP_044380534.1; NZ_CP010849.1.
DR   AlphaFoldDB; A0A0C5FNA7; -.
DR   STRING; 477245.TU94_07325; -.
DR   KEGG; scw:TU94_07325; -.
DR   PATRIC; fig|477245.3.peg.1582; -.
DR   HOGENOM; CLU_012348_1_0_11; -.
DR   OrthoDB; 4317601at2; -.
DR   Proteomes; UP000032234; Chromosome.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0009432; P:SOS response; IEA:UniProt.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR   InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001126; UmuC.
DR   PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR   PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR   Pfam; PF00817; IMS; 1.
DR   Pfam; PF11799; IMS_C; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR   PROSITE; PS50173; UMUC; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000032234}.
FT   DOMAIN          12..123
FT                   /note="UmuC"
FT                   /evidence="ECO:0000259|PROSITE:PS50173"
SQ   SEQUENCE   324 AA;  34635 MW;  65E46AFDABBCC99F CRC64;
     MTILCVRFQL PPMYEAALPR LLGMLEEFTP VVQALPPDGA LADLRGAERY FGRGAVELAS
     VIRVRALALY GVDCVIGAAP GPMLARMALR DARPGATCVV PGDPEGIAEF LAGKPVAALP
     GVGAATARTL CEYGLDTLGR VAAAPLSTLQ RLVGAKTGRE LREKAGGVDR GRVVPNGVSR
     SLATERPFER DELDPDRHRR ALLSAAEELG SRLRALDKVC RTLTLTVRYA DRSATTRSRT
     LAEPTAHSAS LTRAVYGMYE ALGLQRARVR ALALRAEGLG PAEQAAHQLT FDPVDEKVRR
     IEEVADRARA KFGPRAVMPG TLAA
//