ID A0A0C5FQ73_9ACTN Unreviewed; 538 AA.
AC A0A0C5FQ73;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=TU94_12190 {ECO:0000313|EMBL:AJP02137.1};
OS Streptomyces cyaneogriseus subsp. noncyanogenus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=477245 {ECO:0000313|EMBL:AJP02137.1, ECO:0000313|Proteomes:UP000032234};
RN [1] {ECO:0000313|EMBL:AJP02137.1, ECO:0000313|Proteomes:UP000032234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NMWT 1 {ECO:0000313|EMBL:AJP02137.1,
RC ECO:0000313|Proteomes:UP000032234};
RA Wang H., Li C., Xiang W., Wang X.;
RT "Genome sequence of thermotolerant Streptomyces cyaneogriseus subsp.
RT Noncyanogenus NMWT1, the producer of nematocidal antibiotics nemadectin.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; CP010849; AJP02137.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C5FQ73; -.
DR STRING; 477245.TU94_12190; -.
DR KEGG; scw:TU94_12190; -.
DR PATRIC; fig|477245.3.peg.2587; -.
DR HOGENOM; CLU_007082_5_1_11; -.
DR OrthoDB; 9763537at2; -.
DR Proteomes; UP000032234; Chromosome.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06568; GH20_SpHex_like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 2.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000032234};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..538
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002177415"
FT DOMAIN 48..175
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 179..346
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT DOMAIN 353..498
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 342
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 538 AA; 58480 MW; 3DAD6B2499DA1F63 CRC64;
MRRHARHHRT TPRMARLLGT LLLVAAGTFT ATGAAAAPDA AAPVPLDRVI PAPASVDPGG
SPYRITRGTH IRVDGPREAR RVGEYLAGVL RPSTGYRLPV TSRGEGGIRL RLADGPYGSE
GYRLDSRRSG VTITAREPAG LFHGVQTLRQ LLPAAVEKDS AQPGPWLVAG GTIEDTPRYA
WRGAMLDVAR HFFTVDEVKR YIDQIALYKI NKLHLHLSDD QGWRIAVDSW PRLAPYGGST
EVGGGPGGYY TKEQYKEIVR YAGSRHLEVV PEIDMPGHTN AALASYAELN CDGVAPPLYT
GIKVGFSSLC VGKDITYDFI DDVVREVAAL TPGRYFHIGG DEAHSTSHAD YVAFMDRVQP
VVAKYGKTVI GWHQLTGATP AEGALAQYWG LDRTSAAEKA QVAKAAQNGT GLILSPADRS
YLDMKYTKDT PLGLSWAGYV EVRRSYDWDP GAYLPGAPAS AIRGVEAPLW SEAIENSAHI
DHMAFPRLPG IAELGWSPAS THDWDAYKER LAAQAPRWEA LGIGFYRSPQ VPWPAAQE
//
