ID A0A0C5FXK5_9ACTN Unreviewed; 734 AA.
AC A0A0C5FXK5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:AJP02408.1};
GN ORFNames=TU94_13875 {ECO:0000313|EMBL:AJP02408.1};
OS Streptomyces cyaneogriseus subsp. noncyanogenus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=477245 {ECO:0000313|EMBL:AJP02408.1, ECO:0000313|Proteomes:UP000032234};
RN [1] {ECO:0000313|EMBL:AJP02408.1, ECO:0000313|Proteomes:UP000032234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NMWT 1 {ECO:0000313|EMBL:AJP02408.1,
RC ECO:0000313|Proteomes:UP000032234};
RA Wang H., Li C., Xiang W., Wang X.;
RT "Genome sequence of thermotolerant Streptomyces cyaneogriseus subsp.
RT Noncyanogenus NMWT1, the producer of nematocidal antibiotics nemadectin.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP010849; AJP02408.1; -; Genomic_DNA.
DR RefSeq; WP_044382096.1; NZ_CP010849.1.
DR AlphaFoldDB; A0A0C5FXK5; -.
DR STRING; 477245.TU94_13875; -.
DR KEGG; scw:TU94_13875; -.
DR PATRIC; fig|477245.3.peg.2936; -.
DR HOGENOM; CLU_005108_1_1_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000032234; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000032234};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..328
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 734 AA; 75789 MW; 1BDDA1CABDD54528 CRC64;
MATFLYKLGR LAFRRRHFVA LIWVALLTLA GVGAASAPPA GSTSFSIPGT EAQKAFDLLE
ERFPGASADG ATARVVFKAP AGETMTDAGN KATVRKTVQE LSDGSEVASA TDPYTANAVS
KDGTVAYTQV KYDVSGMELE ESTKDALEDA AQQARDAGLT VEIGGDALSA VPETGATEVI
GIAVAAVVLV ITFGSLVAAG LPLLTALIGV GIGVASITAL ANALDLGSTT STLAMMIGLA
VGIDYALFIV SRYRAELAEG REREEAAGRA VGTAGSTVVF AGLTVVIALV GLAVVNIPML
TKMGVAAAGT VAIAVLIALT MIPALLGYAG RKVKPAGEKS KLLGGGRTAG KPAKPNLGTR
WANFVVRRPV AVLLLGVVGL GAAAVPAASL ELGLPDEGSQ PTSTTQRRAY DLLSEGFGPG
FNGPLMVVVD AKASDAPKTV FTDVVDEIKG LDDVAAVTPP APNKAGDTAT ITVVPKSKPS
SVTTEDLVHS IRDAGAGVKA DTGASVLVTG STAMNIDVSQ KLNDALLPYL VLVVGLAFLL
LIVVFRSILV PLKAALGFLL SVLAALGAVV AVFQWGWLAD LMGVEETGPV MSMMPIFMVG
VVFGLAMDYE VFLVTRMREA YVHGETPSQA VVTGFRHGAR VVTAAAVIMM AVFAGFIGSS
ESMVKMIGFG LAIAVFFDAF IVRMALVPAV LALLGRRAWW LPKWLDRALP NVDVEGEGLR
TQADRDADRE AVRV
//
