ID A0A0C5VPG2_9GAMM Unreviewed; 496 AA.
AC A0A0C5VPG2;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=YC6258_00098 {ECO:0000313|EMBL:AJQ92154.1};
OS Gynuella sunshinyii YC6258.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Saccharospirillaceae; Gynuella.
OX NCBI_TaxID=1445510 {ECO:0000313|EMBL:AJQ92154.1, ECO:0000313|Proteomes:UP000032266};
RN [1] {ECO:0000313|EMBL:AJQ92154.1, ECO:0000313|Proteomes:UP000032266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YC6258 {ECO:0000313|EMBL:AJQ92154.1,
RC ECO:0000313|Proteomes:UP000032266};
RA Khan H., Chung E.J., Chung Y.R.;
RT "Full genme sequencing of cellulolytic bacterium Gynuella sunshinyii
RT YC6258T gen. nov., sp. nov.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP007142; AJQ92154.1; -; Genomic_DNA.
DR RefSeq; WP_044615302.1; NZ_CP007142.1.
DR AlphaFoldDB; A0A0C5VPG2; -.
DR STRING; 1445510.YC6258_00098; -.
DR REBASE; 106431; M2.Gsu6258ORF98P.
DR KEGG; gsn:YC6258_00098; -.
DR PATRIC; fig|1445510.3.peg.94; -.
DR HOGENOM; CLU_013049_4_2_6; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000032266; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AJQ92154.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000032266};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AJQ92154.1}.
FT DOMAIN 6..132
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 143..454
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 496 AA; 56659 MW; A58B13F5A72C4D14 CRC64;
MKKADLENLL WGAAEFLRGQ IDASDYKQYI FPLLFYKRLS DVYLEEYTEA LKIHEGDAEY
AAMPMFHRFD IPKEARWEKV RHTSKNIGEA IQNALRLIEA NNPRLHGVFG DAQWTNKERL
PDHLLSDLIE HFSKIPLGIK SVAQDDLGEA YEYLIKKFAD DSGHTAAEFY TNRTVVHLMT
RIMGLKPGET AYDPTCGTGG MLLNAVMDLR THGQEWRSVH LYGQEVNLLT SAIARMNMFL
HDIEEFDVLR GDTLAEPKFI ENDQLKQFDV IFANPPYSIK KWNRDKFAAD PYGRNLYGVP
PQGCADYAFY THIIKSLKPD TGRAAMLWPH GVLFRDSEQS IRKQVIESDI IEAVIGLGPN
LFYNSPMESC VVVLNCNKPS ERKNKVLFIN GVEHVTRERA HSRLSDGDLA VLCEAYFVPE
KQSNITALVD IDTLKENLYN LSIPLYVQSQ NNSEVHDIEH AIEAWKVSRV QLKKQTNKLF
KSLKELGFEV GGEEVQ
//
