ID A0A0C7MRZ1_9SACH Unreviewed; 577 AA.
AC A0A0C7MRZ1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
DE AltName: Full=Methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030904};
GN ORFNames=LALA0_S06e01904g {ECO:0000313|EMBL:CEP62709.1};
OS Lachancea lanzarotensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=1245769 {ECO:0000313|EMBL:CEP62709.1, ECO:0000313|Proteomes:UP000054304};
RN [1] {ECO:0000313|EMBL:CEP62709.1, ECO:0000313|Proteomes:UP000054304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 12615 {ECO:0000313|EMBL:CEP62709.1,
RC ECO:0000313|Proteomes:UP000054304};
RA Neuveglise Cecile;
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363039}.
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DR EMBL; LN736365; CEP62709.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C7MRZ1; -.
DR STRING; 1245769.A0A0C7MRZ1; -.
DR HOGENOM; CLU_009710_9_0_1; -.
DR OrthoDB; 166496at2759; -.
DR Proteomes; UP000054304; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00814; MetRS_core; 1.
DR Gene3D; 2.170.220.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR041872; Anticodon_Met.
DR InterPro; IPR014758; Met-tRNA_synth.
DR InterPro; IPR023457; Met-tRNA_synth_2.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR033911; MetRS_core.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00398; metG; 1.
DR PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR Pfam; PF19303; Anticodon_3; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR01041; TRNASYNTHMET.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039};
KW Reference proteome {ECO:0000313|Proteomes:UP000054304}.
FT DOMAIN 19..411
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
FT DOMAIN 460..539
FT /note="Methionyl-tRNA synthetase anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF19303"
SQ SEQUENCE 577 AA; 65814 MW; 46D4AC80BD80E880 CRC64;
MKTSFQKTLK EVWRGQTYHI TTPIFYPNAR PHLGHLYSSL LCDVSKRWHA MLGQRSLLTT
GTDEHGLKIQ AASEKNGFAS PKPFVDKLCQ DFIKLDQQAN VDYTRFIRTT DPDHIECVQK
LWNRCWERGY IYKGKHDGWY SVSDECFYPD SKIVQIGIDG QELALSHSDI DNDKPFINTE
TRNEVVYHTE TNYFFKLSAF QDQLLSYLEK ENPEFIFPAT RRQHILNELR ESHLRDLSVS
RPSSRIRWGI DVPQDSSQKI YVWFDALCNY LTSVGGFDAV AEKKNVVLKH KGVEIAQDAH
HWWINTTHLI GKDIAKFHTI YWPAFLLAAG LPLPKQIIVH GHWLSGGTKM SKSLGNVVDP
LEMISYYGCD PVRWYVLENS HIEADGDFRE ERLHSTREQL VSKWGNLLNR CCGSKFDLSR
AIKTFCSADG SRQKLLESLN DPGLLAAFSS LEQKLGCLPS SFHDKIEKLD TRSALSLLRD
VINEANAFVQ TSTPWLKSGV EQDAILFMAV EVVRITAILS QPIIPSLSRQ LLDRLDVSHS
KRSLGDVILG ADHAYASRAN EKGRPVAIKR IPLRVKT
//