ID   A0A0C7MTP0_9SACH        Unreviewed;       849 AA.
AC   A0A0C7MTP0;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Patatin-like phospholipase domain-containing protein {ECO:0000256|RuleBase:RU362055};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU362055};
GN   ORFNames=LALA0_S01e18140g {ECO:0000313|EMBL:CEP60752.1};
OS   Lachancea lanzarotensis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=1245769 {ECO:0000313|EMBL:CEP60752.1, ECO:0000313|Proteomes:UP000054304};
RN   [1] {ECO:0000313|EMBL:CEP60752.1, ECO:0000313|Proteomes:UP000054304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 12615 {ECO:0000313|EMBL:CEP60752.1,
RC   ECO:0000313|Proteomes:UP000054304};
RA   Neuveglise Cecile;
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lipid hydrolase. {ECO:0000256|RuleBase:RU362055}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362055}; Single-
CC       pass membrane protein {ECO:0000256|RuleBase:RU362055}.
CC   -!- SIMILARITY: Belongs to the PLPL family.
CC       {ECO:0000256|RuleBase:RU362055}.
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DR   EMBL; LN736360; CEP60752.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C7MTP0; -.
DR   STRING; 1245769.A0A0C7MTP0; -.
DR   HOGENOM; CLU_009031_4_0_1; -.
DR   OrthoDB; 154387at2759; -.
DR   Proteomes; UP000054304; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR   CDD; cd07230; Pat_TGL4-5_like; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR021771; Triacylglycerol_lipase_N.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   PANTHER; PTHR14226:SF10; TRIACYLGLYCEROL LIPASE 4-RELATED; 1.
DR   Pfam; PF11815; DUF3336; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362055};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW   ECO:0000256|RuleBase:RU362055};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|RuleBase:RU362055};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054304}.
FT   DOMAIN          224..424
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          645..682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          718..849
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        733..774
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        796..810
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   849 AA;  94819 MW;  0734835C018147A1 CRC64;
     MVKGEFSLNG EPVDITQRLI HRYYDALWAA KNDVDLNGSS SANENANNLS EGDDCYSDDA
     SGGTFRKLAS IVKRMFSRDY ERNVLIEKVT QEKQHATSYE EWLAAALRLD ELTRTNEWKA
     REESVLYDYK FIQTHTQNMR QARLDKDYAQ LLYLIRTTWI RNLGNMGNVN LYRHSHVGTK
     YVIDDYMRES KLALQELVRH SDLDESYLLG MLVQTRKNIG RTALVLSGGG TFGLFHIGVL
     STLLEQDLLP RVISGSSAGA IVASILCSCH RREIVGLVES VLEKELNIFQ DDSEKTQGEN
     LLIKISRFFK SGTWFDNKNL VKTMIDFLGD LTFREAYNRT GKILNITVSP ASVFEQPGLL
     NNLTAPNVLI WSAVCASCSL PGIFPSTPLY EKDAKTGETR EWNSGTVKFV DGSVDNDLPI
     SRLSEMFNVD HIIACQVNLH VFPILKMSVS CVGGEIEDEF SARFRQNLSS VYNFVSNEII
     HVLEIVTELG IATNVLTKFR SILSQQYSGD ITILPDIKML FRLNELLANP STDFLLRETV
     NGARATWPKI SIIKNHCEQE FELDKAISYL KGKIISNPTF TTKNPFQFTD LSISLINTPE
     MPSHDEQVPN DLDDTLLNHH ETDRMLVIND SSKRPHSYGK TSISIADAGR SLHHHRRKSD
     SYAKGKSGAR YSISHPGTTT SHISTKLLPT LMGYSPRLDR KKSVGQLPSA SVASRPLDNN
     FRLEPKRHSS SFTALHGPRN SNVYSSVRTN PPSPLSAPIN TNMEGTSRKG SFSSYESPLK
     AYHKRGAKAH KGRAPAGNRS NSTGSAKLKS SGKVKTGGKP DLKTVSYVDD DPMDPVETGG
     DEEINRESN
//