ID A0A0D0VVJ3_9ACTN Unreviewed; 378 AA.
AC A0A0D0VVJ3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:KIR64778.1};
GN ORFNames=TK50_04000 {ECO:0000313|EMBL:KIR64778.1};
OS Micromonospora haikouensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=686309 {ECO:0000313|EMBL:KIR64778.1, ECO:0000313|Proteomes:UP000032254};
RN [1] {ECO:0000313|EMBL:KIR64778.1, ECO:0000313|Proteomes:UP000032254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JXNU-1 {ECO:0000313|EMBL:KIR64778.1,
RC ECO:0000313|Proteomes:UP000032254};
RA Long Z., Huang Y., Jiang Y.;
RT "Sequencing and annotation of Micromonospora carbonacea strain JXNU-1
RT genome.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIR64778.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JXSX01000001; KIR64778.1; -; Genomic_DNA.
DR RefSeq; WP_043961521.1; NZ_JXSX01000001.1.
DR AlphaFoldDB; A0A0D0VVJ3; -.
DR PATRIC; fig|47853.6.peg.854; -.
DR OrthoDB; 3399630at2; -.
DR Proteomes; UP000032254; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08282; PFDH_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF3; GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000032254};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 25..134
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 185..288
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 378 AA; 40246 MW; 7B54AC9DC4A6A68F CRC64;
MRAVVYQGPH EVAVNEVPDP RIEAPNDVIV RITTTAICGS DLHMYEGRTL AEPGIVFGHE
NMGVVEEVGP GVVHIRKGDR VSMPFNVACG FCRNCREGKT GFCLTVNPGF AGGAYGYVAM
GPYRGGQAEY LRVPFADFNC LRLPPGTEHE NDFAMLADIF PTGYHGVAMT GLRPGENITV
MGGGPVGLMA AYSALLMGAA EVFLVDKVPD RLRLAESIGA IPVDFTAGDP VEQIREQTDG
VGTDRGVDAV GYQASGAGGE EHPAAVLNSL VDVVRPTGSL GVVGLYLAHD PGAPDERAGR
GELVFKVGKF FEKGLRMGTG QANVKSYNEY LRNLIMAGRA KPSFVVSKEL PLADAPEAYQ
RFDQREAGYS KVVLKPAA
//
