ID A0A0D1JAG5_9MYCO Unreviewed; 530 AA.
AC A0A0D1JAG5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Adenylate cyclase {ECO:0008006|Google:ProtNLM};
GN ORFNames=TL10_01405 {ECO:0000313|EMBL:KIU18523.1};
OS Mycolicibacterium llatzerense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=280871 {ECO:0000313|EMBL:KIU18523.1, ECO:0000313|Proteomes:UP000032221};
RN [1] {ECO:0000313|EMBL:KIU18523.1, ECO:0000313|Proteomes:UP000032221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLUC14 {ECO:0000313|EMBL:KIU18523.1,
RC ECO:0000313|Proteomes:UP000032221};
RA Greninger A.L., Langelier C., Cunningham G., Chiu C.Y., Miller S.;
RT "Genome sequence of Mycobacterium llatzerense and Mycobacterium immunogenum
RT recovered from brain abscess.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIU18523.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JXST01000002; KIU18523.1; -; Genomic_DNA.
DR RefSeq; WP_043984193.1; NZ_JXST01000002.1.
DR AlphaFoldDB; A0A0D1JAG5; -.
DR STRING; 280871.TL10_01405; -.
DR PATRIC; fig|280871.6.peg.284; -.
DR OrthoDB; 368920at2; -.
DR Proteomes; UP000032221; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000032221};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 273..325
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 357..481
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 530 AA; 57341 MW; 918A54FA054A2733 CRC64;
MTADQAGTTR LVRIREAITP RTTTPEYGSW ILGRVSESHR RRRIRIQLIL TTFVIVANMI
GVGVSIFIET VLFPTPNVFR ADVWWITTIV APTYILLAFL IGVVWATNRV IQSVRWAIEE
RTPTIEDQRN TFRAPGQLTL VLLCLWGAGA ALLTTLYALH DTQFIPKLLL GVTFPGIVVS
TSCNLYTEFA LRPVAADALQ AGRPPSRLAP GIMGRTMVVW AFGSGVPMLG VLLAAVFALT
QSTLTPTQFA FAVLVLAVFA LVFGALLMWI VSWLTASPIR IVRQALSRVE QGDLTTDLVV
FDGTELGQLQ RGFNSMVHGL RERERVRDLF GRHVGREVAA LAEQEKPQLG GEERHAAVIF
VDVIGSTQLV TSRPAVEVVA LLNRFFAVIV DEVDRHHGFV NKFEGDAVLA VFGAPVSLQC
TEGDALAAAR AIASRLRDEV PELKAGLGVA AGTVVAGNVG AKERFEYTVI GEPVNAAARL
CELAKSVPGH LAAAAAMLDA VSESERANWA LGDTVTLRGL SEPTQLAILA
//
