ID A0A0D1LIF4_9MYCO Unreviewed; 422 AA.
AC A0A0D1LIF4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=3-oxoacyl-ACP synthase {ECO:0000313|EMBL:KIU15811.1};
DE EC=2.3.1.179 {ECO:0000313|EMBL:KIU15811.1};
GN ORFNames=TL10_17130 {ECO:0000313|EMBL:KIU15811.1};
OS Mycolicibacterium llatzerense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=280871 {ECO:0000313|EMBL:KIU15811.1, ECO:0000313|Proteomes:UP000032221};
RN [1] {ECO:0000313|EMBL:KIU15811.1, ECO:0000313|Proteomes:UP000032221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLUC14 {ECO:0000313|EMBL:KIU15811.1,
RC ECO:0000313|Proteomes:UP000032221};
RA Greninger A.L., Langelier C., Cunningham G., Chiu C.Y., Miller S.;
RT "Genome sequence of Mycobacterium llatzerense and Mycobacterium immunogenum
RT recovered from brain abscess.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; mycolic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004796}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIU15811.1}.
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DR EMBL; JXST01000023; KIU15811.1; -; Genomic_DNA.
DR RefSeq; WP_043986526.1; NZ_JXST01000023.1.
DR AlphaFoldDB; A0A0D1LIF4; -.
DR STRING; 280871.TL10_17130; -.
DR PATRIC; fig|280871.6.peg.3551; -.
DR OrthoDB; 9808669at2; -.
DR UniPathway; UPA00915; -.
DR Proteomes; UP000032221; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:KIU15811.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516};
KW Reference proteome {ECO:0000313|Proteomes:UP000032221};
KW Transferase {ECO:0000256|RuleBase:RU003694, ECO:0000313|EMBL:KIU15811.1}.
FT DOMAIN 15..421
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 422 AA; 44420 MW; ED913D039FB93FAE CRC64;
MAGVTANRLS TGNGLPNVVV TGIAMSTALA TDAETTWQKL LAGESGIRLL NDSFIEEYDL
PVRIGGHLLE DFESELTRIE LRRLSYLQKM STVIGRRVWE NAGSPDVDPR RLMVSIGTGI
GSAEELVFAY DGMRERGLRA VSPLVVQMFM PNGAAAAVGL DRKAKAGVST LISACASGSE
AIANAWRQLV LGEADVAICG GVETKIEAVP IAGFAQMRIV LSNSNDNPQG ACRPFDRDRN
GFVFGEGGAM LVLETEEHAK ARGANILARL MGASVTSDGY HIVAPDPNGE QAGYAMSRAI
ELAGLVPSDI DHINAHATGT SVGDVAEGVA INKAMKGHRP AVYAPKSALG HSVGAVGAVE
SILTVLALRD GVVPPTLNLE NLDPEIDLDV VSKAPRQGDY KYAINNSFGF GGHNVALAFG
RY
//
