ID A0A0D1LRZ2_9MYCO Unreviewed; 1209 AA.
AC A0A0D1LRZ2;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=TL10_01210 {ECO:0000313|EMBL:KIU18881.1};
OS Mycolicibacterium llatzerense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=280871 {ECO:0000313|EMBL:KIU18881.1, ECO:0000313|Proteomes:UP000032221};
RN [1] {ECO:0000313|EMBL:KIU18881.1, ECO:0000313|Proteomes:UP000032221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLUC14 {ECO:0000313|EMBL:KIU18881.1,
RC ECO:0000313|Proteomes:UP000032221};
RA Greninger A.L., Langelier C., Cunningham G., Chiu C.Y., Miller S.;
RT "Genome sequence of Mycobacterium llatzerense and Mycobacterium immunogenum
RT recovered from brain abscess.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIU18881.1}.
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DR EMBL; JXST01000001; KIU18881.1; -; Genomic_DNA.
DR RefSeq; WP_043984072.1; NZ_JXST01000001.1.
DR AlphaFoldDB; A0A0D1LRZ2; -.
DR STRING; 280871.TL10_01210; -.
DR PATRIC; fig|280871.6.peg.244; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000032221; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR CDD; cd18810; SF2_C_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000032221}.
FT DOMAIN 656..817
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 835..992
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1209 AA; 129718 MW; C8FD90F719BDD459 CRC64;
MTSPGQQSIQ TPLAGLVQLA LTDPGLQELT RQAAEGIAEQ ALVGPVSARL PVAAALAAAG
PVLVVTATGR EADDLTAELR AVHGDAVALF PSWETLPHER LSPGVDTVGA RLTVLRRLAR
PDDTRLGPPL RVVVTTARSL LQPLAGGVTD AEPVTLTVGG EADFDDTVTR LVELAYNRVD
MVGKRGEFAV RGGILDIFTP TAEHPVRIEF WGDEVTEMRM FSVADQRSIP EIAVETMIAV
PCRELLLTPD VRERAAEIGA SLPSSDNQVT GSIADMMAKL AEGIPVDGME ALLPVLRPGD
LALLTDRLPA GAPLLICDPE KVRTRAADLI KTGREFLEAS WSVAAVGGDA PIDVEQLGGS
GFRDFVEIRE AAAAGGHPWW TLSQLANETA VEVDIRPAPS ARGQQSLEEI FAMLRAHIAT
GGLAAVVTPG AGTAHRVVEQ LSESDVAATM LEPGAVPKAG VVGVLKGPLH DGLVLPGVNL
VVITETDLTG NRAAATEGKR LAAKRRNVVD PLALTAGDLV VHDQHGIGKF IEMTERVVGG
ARREYLVLEY GSSKRGGGSD RLYVPMDSLD QLSRYVGGTE PTLSRLGGSD WTNTKTKARK
AVREIAGELV SLYAKRQSAP GHAFAPDTPW QNEMEDAFGF TETMDQLTAI TEVKADMEKP
VPMDRVICGD VGYGKTEIAV RAAFKAVQDG KQVAVLVPTT LLADQHLQTF AARMAGFPVT
VKGLSRFTDP AESRLVIEGL KDGSVDVVIG THRLLATGVT WKDLGLVIVD EEQRFGVEHK
EHIKSMRTHV DVLTMSATPI PRTLEMSLAG IREMSTILTP PEERFPVLTY VGPHDDKQVA
AALRRELLRD GQAFYIHNRV KSIDSAAARV RQLVPEARVV VAHGQMPEEL LEKTVEGFWN
RDYDILVCTT IVETGLDISN ANTLIVERAD TFGLSQLHQL RGRVGRSRER GYAYFLYPPE
VPLTETAHDR LATIAQNNDL GAGMAVAMKD LEIRGAGNVL GVEQSGHVAG VGFDLYVRLV
GEAVEAYRAA VDGKTIAAVE EVKEVRVDLP IDAHLPPDYI GSDRLRLEAY RRLAAASDHA
RVASVVEELV DRYGPLPEPA QRLVAVARLR LLCREYGVTE VTAISDSTIR LTPLTLMDSG
QLRLKRMYPG ATYRATTSTV QIPIPRAGAG VGAPRIRDLE LARAVAGLLL ELDGKAPGEV
DITDLGGSA
//
