ID A0A0D2AQQ3_9EURO Unreviewed; 656 AA.
AC A0A0D2AQQ3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=PV06_05853 {ECO:0000313|EMBL:KIW42291.1};
OS Exophiala oligosperma.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=215243 {ECO:0000313|EMBL:KIW42291.1, ECO:0000313|Proteomes:UP000053342};
RN [1] {ECO:0000313|EMBL:KIW42291.1, ECO:0000313|Proteomes:UP000053342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 72588 {ECO:0000313|EMBL:KIW42291.1,
RC ECO:0000313|Proteomes:UP000053342};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala oligosperma CBS72588.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable lipid hydrolase. {ECO:0000256|ARBA:ARBA00002682}.
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DR EMBL; KN847336; KIW42291.1; -; Genomic_DNA.
DR RefSeq; XP_016262507.1; XM_016406903.1.
DR AlphaFoldDB; A0A0D2AQQ3; -.
DR STRING; 215243.A0A0D2AQQ3; -.
DR GeneID; 27357927; -.
DR VEuPathDB; FungiDB:PV06_05853; -.
DR HOGENOM; CLU_009031_5_1_1; -.
DR OrthoDB; 154387at2759; -.
DR Proteomes; UP000053342; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF10; TRIACYLGLYCEROL LIPASE 4-RELATED; 1.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000053342}.
FT DOMAIN 202..401
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 552..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 656 AA; 73513 MW; C558B225CE6AC002 CRC64;
MTVLSSPIPT YTSTQLFWSC VGIYADVVKL CSPSKKLSRL ADGVARFSRR PPESPTQTLT
RAMNGASTLE EYERCTIALD QVQGHEQWKQ EKESLEPGYN PDVIETQMAL LEKGVAMSDV
SAIHHVLRTG LSRDLGGMNM LRLYKHSWFG TKTLIDDYTN TVLESIDKFI DMAIHYQLPA
TEVRFYQQSL EDALKYFGRS ALTLSGGALL GMKHIGVVKT LWEADLLPEI ISGASAGSIV
AAIVGSSTDE RMLEVLEHFP NSDLACFDPP GTTSVAWLLQ RVRTYARTGA FFDMSNLERV
MKSWLGDITF REAHYKTGRI LNICVSSASS AEPRLLNYVT APDVLLWSAV CASCAVPHVF
SPVSIYEKDP MTKSGKLWME NAQQTFVDGS LDHDIPMRKL SEMFNVNFFI VSQVNPHVRV
LLDPEERFDG MQPTTPSPRH TPIQKAKVLV RQEIIHRAQQ LSDLGVPQNW YRWASLFNQQ
YTGDINILPE IKYSEYLHMM MNPTPTFMLE STMAGQKATW PKMCRIKNCV AIELALIRAI
HTLRDRANFG PEARAAREAK RSTSRGRSRR GRSARPAFYR QRSLSIGSPD LADNSSTTVT
PLRVRRNVSL GSINVKQVTP FSVTPRTTPF LTPSVSMDSD LLNEALLMTN TNGKAW
//
