ID A0A0D2AWP4_9EURO Unreviewed; 822 AA.
AC A0A0D2AWP4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN ORFNames=PV08_10418 {ECO:0000313|EMBL:KIW11118.1};
OS Exophiala spinifera.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=91928 {ECO:0000313|EMBL:KIW11118.1, ECO:0000313|Proteomes:UP000053328};
RN [1] {ECO:0000313|EMBL:KIW11118.1, ECO:0000313|Proteomes:UP000053328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 89968 {ECO:0000313|EMBL:KIW11118.1,
RC ECO:0000313|Proteomes:UP000053328};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala spinifera CBS89968.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; KN847499; KIW11118.1; -; Genomic_DNA.
DR RefSeq; XP_016231334.1; XM_016384732.1.
DR AlphaFoldDB; A0A0D2AWP4; -.
DR STRING; 91928.A0A0D2AWP4; -.
DR GeneID; 27337501; -.
DR VEuPathDB; FungiDB:PV08_10418; -.
DR HOGENOM; CLU_010129_0_1_1; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000053328; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000053328};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 449..529
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 679..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 822 AA; 92421 MW; EE613710F00C3D89 CRC64;
MTSEDSKEAA ADLTADFKSF QDQVQKALVN ATRTAGRVAN EDLGFHRSSS EKLSRALDRQ
NAHLLRLTNK LLKAATTDTS IKPPTLQSPD GIDDNWRRVV DIVDDLLEKA DSALDEVSGV
IKRHSPSLKE GDLPSQNAKL VRDRFSNVMQ KPQVHFEKKV NNNDTKPFKP LLRSKPHAQV
PLEECMVEEE SGYKHPYAPE IEDYTYPPSV YEIKPPIPFL PPENTEPIYV DTEEGVKEML
DELKQASEIA IDLEHNDMRS FVGMVCLMQI STREKDWIID TLKPWRENLQ MLNEVFADPK
ILKLFHGSNM DMIWLQRDLG LYVVGLFDTF HASMALHFEG KSLKYLLQRF ANFEAQKQYQ
VADWRVRPLP KELLDYARSD THFLLHIYDN VRNMLVEAST PNENLVDYVL RESKKESLQV
YERPLYDAET GRGSLGWLNL LLQRSVTFGP EQFSVFRAVH EWRDRKARET DEGLQFIMSN
QVLFQIAETM PTSAFNFHAT IRRNTKAISN YLPELIEVIK KAKAEGKEGK TVQEVLKHAE
TAYGIFPRRG PRFQPRREQQ TTYDGVGATL KQLVATAANE SVSSSAVLAF DIPVATRSAS
SHLWGTITPN HEHVATEPAT AFAALASVLP LPTVHAPELV AQQPTEPGPV DISQTTVPIE
TAPSRLLQQT KSKEIFTLKE RSRSKKRKAG ETDTIEEQIA TTLPSMADSS ASADPDQADD
QEAAQTLDPA YADKRLAKKQ KKAEKKARKQ AEKLAAEQAA QEIKPFDYAS AESLLTSTAE
SGPKAQPTKK MNPFAKALDT STGARRNKMG KEMSGKSMTF KS
//
