ID A0A0D2B028_9PEZI Unreviewed; 575 AA.
AC A0A0D2B028;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN ORFNames=PV09_04461 {ECO:0000313|EMBL:KIW04729.1};
OS Verruconis gallopava.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Venturiales; Sympoventuriaceae; Verruconis.
OX NCBI_TaxID=253628 {ECO:0000313|EMBL:KIW04729.1, ECO:0000313|Proteomes:UP000053259};
RN [1] {ECO:0000313|EMBL:KIW04729.1, ECO:0000313|Proteomes:UP000053259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 43764 {ECO:0000313|EMBL:KIW04729.1,
RC ECO:0000313|Proteomes:UP000053259};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Ochroconis gallopava CBS43764.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00029358};
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC {ECO:0000256|ARBA:ARBA00025711}.
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DR EMBL; KN847540; KIW04729.1; -; Genomic_DNA.
DR RefSeq; XP_016214598.1; XM_016357806.1.
DR AlphaFoldDB; A0A0D2B028; -.
DR STRING; 253628.A0A0D2B028; -.
DR GeneID; 27312434; -.
DR VEuPathDB; FungiDB:PV09_04461; -.
DR HOGENOM; CLU_018822_0_1_1; -.
DR InParanoid; A0A0D2B028; -.
DR OrthoDB; 5474505at2759; -.
DR UniPathway; UPA00363; UER00861.
DR Proteomes; UP000053259; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR045190; MCCB/AccD1-like.
DR PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR22855:SF13; METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053259}.
FT DOMAIN 65..322
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 333..565
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 61939 MW; F789FE820C220ED5 CRC64;
MASSVPRHTM LRSAGAALKR KRTQPPHCRR AIATHTHSHH AGQISVLRSS VDTSSADFKE
NAAAMAEVVA KMKELRERLS QGGPQKAREK HVQRGKMLPR DRITALIDPG TSFLELSPFA
GHNLYQGEDV PSGGILTGIG TVSGVTCMII ANDSTVKGGT YYPITVKKHL RAQEIAHQNR
LPCIYLVDSG GANLPHQADV FPDRDHFGRI FFNQARMSGE GIPQLSVVMG PCTAGGAYVP
SMSDESIIVD KQGHIFLAGP PLVKAATGEE ISAEELGGGR LHSEISGVTD YLAVDDAHAL
VLARRCVLNY NWPKGKAVSV GSLDTEGKVY TKPWKEPLYD PQELGGIVGT NLRRQIPAHE
VIARIVDGSE FSEFKKDYGP TLVTGFAHIQ GQQVGILANN GILFSPSSLK GAHFIQLCAA
RNIPLLFLQN ISGFMVGRDS EAGGIAKNGA KLVTAVACAN VPKFTVVFGS SAGAGNYGMC
GRAYSPRMLW TWPNAKTSVM GPEQLSAVME AVGRKDEGLR ERIEKESEAL FGSARLWDDG
IIEPALTRDY VGMGLRTVNG GSVEERETKF GVFRM
//
