ID   A0A0D2CXD4_9EURO        Unreviewed;      1646 AA.
AC   A0A0D2CXD4;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PV04_02157 {ECO:0000313|EMBL:KIW69831.1};
OS   Phialophora macrospora.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Phialophora.
OX   NCBI_TaxID=1851006 {ECO:0000313|EMBL:KIW69831.1, ECO:0000313|Proteomes:UP000054266};
RN   [1] {ECO:0000313|EMBL:KIW69831.1, ECO:0000313|Proteomes:UP000054266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 27337 {ECO:0000313|EMBL:KIW69831.1,
RC   ECO:0000313|Proteomes:UP000054266};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Capronia semiimmersa CBS27337.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN846957; KIW69831.1; -; Genomic_DNA.
DR   STRING; 5601.A0A0D2CXD4; -.
DR   HOGENOM; CLU_000972_1_1_1; -.
DR   OrthoDB; 12619at2759; -.
DR   Proteomes; UP000054266; Unassembled WGS sequence.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   CDD; cd21206; CH_IQGAP; 1.
DR   CDD; cd05127; RasGAP_IQGAP_like; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00015; IQ; 6.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50096; IQ; 9.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          258..364
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          1010..1226
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          36..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1471..1505
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        36..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..114
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1646 AA;  188951 MW;  1F0AB26574054C22 CRC64;
     MSHYALRRAQ TDNQYGLPHR QTSVASTVSS AYSTASSAFL PSRTSTVTST NSSIYSTGSP
     GHKRSNTTVE EMTPTKPYAG SSSVENSPDH VYRNIRQSLR PLPQAPSPTA KPNGRRSSPY
     HARAQTIDHF PQTYSEDLFV DKQHLLEHHQ DSYKARPHLH HSMTSPHSNT FKAPDLQDLQ
     KSSTGYLKTL SRFAQNGEAE EFGITRPGQS VVGLHNRRQL KRTDSLAPGG RPTAKHYGWG
     DRNWMDKQRQ FLQAYEYLCH IGEAKEWIED IIDKQIPPIV QLEEALRDGV TLAEIVQAFH
     PDQKLRIFRN PKLQFKHSDN IVLFFRFLED VGLPDLFRFE LIDLYEKKNI PKVIYCIHAL
     SWLLYRKGMV DFRIGNLVGQ LEFEHHELEQ TQRGLDKAGI SMPSFSGMGA SFGEPEPEPE
     PEPVETEDER IERELHEQEA VIVDFQNQVR GALVRLRLGD MMQQLWDAEG VIVDLQSHIR
     GDWSRQIAEY RLDMQRFATS LQAASRGFLA RQRQIRTKQA WKSTEDKVLK LQSLFRADRV
     RAETRTLKSQ FRKHDPGIRN LQAAIRGALS RRDAFDQYEE TRTAENEVLS LQANIRGMLA
     RSQLQNDHAT LELHSRPIMQ LQAAARALVA RAAHGRMDDA LRRSAPQWIG LQAVARAGQV
     RAGVARLKQA LRSHSSSVDK FQAALRGANV REKYSSLKLA LLRQSSSTIP LQAVIRGYSL
     RRTLQRQQQL LDRHIPRISQ LQALGRGALL RIQTAKLLGE LDDMQEEVIQ LQALSRAMLC
     RAHVGDLLSE LETHEASITE LQAIMRATAI RTRFAEKQRH YKENMEKVVK IQSVVRAKIQ
     GKAYKSLTAG KNPPVGTLKG FVHLLNDSDF DFEEEVEFER LRKTVVQHVR QNELADQYIT
     QLDIKIALLV KNKITLDEVV KHQRHFGGHV GALLPNSDIA SKDPFDLKAL NKTSRRKLEH
     YQELFFLLQT QPQYLSRLLR RIREHATAEK ECDRIKHLVM GIFGYAQKRR EEYYLVKLIA
     RSIKEEVDCS ISFQDYLRTN SFSNKLFAAY SKSPRDRKFL RDVLGPVVKE NIIDNTTLDL
     ESDPLQIYVS AINNEELRTG RRSQRDPNVP REVAIRDPET RATFIAHMQD LRDITDQFFL
     CLEDCLQRMP FGIRFVVQQT YQHLVARFPG EEADFVLQLV GQWLWRHYLQ PALLEPEKFG
     VADRAMTQEQ KRNLGEIAKV LNQAATGREF GGDNVYLQPL NNYVRESIER FAVIWSHVIS
     IPPAEEHYDI DEFNDLYAKT KPTLYIKMAD IFSIHKLLSQ EISAICPSQD DVLRDTLREL
     GSVQSNESEL RGVSSSEISL TLNPKLLNSE DPDADVKALL TETKRCVLYI IRIQSGASLL
     EILVKPINPE DEEKWEALVT EELQSGSGRR GAYADANNHL DILSLSYPDL KRIALENILQ
     LESIGRLTRA NQYQDLLNSI AVDIRTKHRR RLQRQRELEN VRTTLERLNE QAVYLEQQLK
     TYNDYIEQAM VTLQNKKGKK RFVMPFSKQW EHERELQRSG RSFKFGSYKY SARTLADKGV
     LVQWRGYNER QWDRVDLTIS SNAVGVFTID GSSGNMMIPG ANAQVPLDDL LQAQFNNTQF
     MEFFEGALRV NVNLFLHLIM KKFYNE
//