ID A0A0D2EKE3_9EURO Unreviewed; 500 AA.
AC A0A0D2EKE3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=phosphatidylinositol N-acetylglucosaminyltransferase {ECO:0000256|ARBA:ARBA00012420};
DE EC=2.4.1.198 {ECO:0000256|ARBA:ARBA00012420};
DE AltName: Full=GlcNAc-PI synthesis protein {ECO:0000256|ARBA:ARBA00032160};
GN ORFNames=PV05_07427 {ECO:0000313|EMBL:KIW55120.1};
OS Exophiala xenobiotica.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=348802 {ECO:0000313|EMBL:KIW55120.1, ECO:0000313|Proteomes:UP000054342};
RN [1] {ECO:0000313|EMBL:KIW55120.1, ECO:0000313|Proteomes:UP000054342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 118157 {ECO:0000313|EMBL:KIW55120.1,
RC ECO:0000313|Proteomes:UP000054342};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala xenobiotica CBS118157.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalytic subunit in the complex catalyzing the transfer of
CC N-acetylglucosamine from UDP-N-acetylglucosamine to
CC phosphatidylinositol, the first step of GPI biosynthesis.
CC {ECO:0000256|ARBA:ARBA00003265}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
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DR EMBL; KN847320; KIW55120.1; -; Genomic_DNA.
DR RefSeq; XP_013315704.1; XM_013460250.1.
DR AlphaFoldDB; A0A0D2EKE3; -.
DR STRING; 348802.A0A0D2EKE3; -.
DR GeneID; 25329335; -.
DR HOGENOM; CLU_009583_19_2_1; -.
DR OrthoDB; 24420at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000054342; Unassembled WGS sequence.
DR GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; IEA:InterPro.
DR GO; GO:0017176; F:phosphatidylinositol N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03796; GT4_PIG-A-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR039507; PIG-A/GPI3.
DR InterPro; IPR013234; PIGA_GPI_anchor_biosynthesis.
DR PANTHER; PTHR45871; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN; 1.
DR PANTHER; PTHR45871:SF1; PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR Pfam; PF08288; PIGA; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054342};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 430..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..131
FT /note="PIGA GPI anchor biosynthesis"
FT /evidence="ECO:0000259|Pfam:PF08288"
FT DOMAIN 211..341
FT /note="Glycosyl transferase family 1"
FT /evidence="ECO:0000259|Pfam:PF00534"
SQ SEQUENCE 500 AA; 56380 MW; 78D955DDF52718B0 CRC64;
MPYNIAMVSD FFFPQPGGVE SHIYQLSTKL IDRGHKVVVI THAYKGRTGV HYLTNGLKVY
HVPFLVIYRE TTMPTVFSFF PVFRNIVIRE QIQIVHGHGS LSSLCHEAIL HGRTMGLRTV
FTDHSLFGFA DAASILTNKL LKFALSDVDH VICVSHTCKE NTVLRASLDP LMVSVIPNAV
VAENFQPRHY VPKTDDVGYM RPRPLPQRLG PGDTIVIVVI SRLFYNKGTD LLIAAIPRIL
AAHPNVRFII AGSGPKAIDL EQMLERQMLQ DKVELLGPVR HEEVRDVMVR GHIYLHPSLT
EAFGTVIVEA ASCGLYVVCT RVGGIPEVLP AHMTTFAKPE EDDLVMATGK AIAALRSGKV
KTERFHDQVK MMYSWTDVAQ RTERVYDGIT GAIGEQEFYG QYASANWSAT RGRSYALIDR
LKRYYGCGIW AGKLFCLCVI IDYLIFFFLE IWAPRASIDI ARSWPRKPFI NDKNKPVENG
MLRWRGTDLM DRRNGSLVMR
//
