ID A0A0D2F6C3_9EURO Unreviewed; 366 AA.
AC A0A0D2F6C3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z517_05254 {ECO:0000313|EMBL:KIW82227.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW82227.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW82227.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW82227.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; KN846971; KIW82227.1; -; Genomic_DNA.
DR RefSeq; XP_013286035.1; XM_013430581.1.
DR AlphaFoldDB; A0A0D2F6C3; -.
DR STRING; 1442368.A0A0D2F6C3; -.
DR GeneID; 25304744; -.
DR VEuPathDB; FungiDB:Z517_05254; -.
DR HOGENOM; CLU_026673_20_2_1; -.
DR OrthoDB; 5353053at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF14; NADP-DEPENDENT ALCOHOL DEHYDROGENASE C; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 34..152
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 194..319
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 366 AA; 39843 MW; C9055475AFF1F1AF CRC64;
MGYPDTFEGF MIEDQKKWTE FKKQEFKPKK FGDHDIDIKI ECCGVCGSDV HTINGGWGEA
PLPICVGHEV VGHAVKVGDA VKTVKVGDRV GVGAQIWACL KCPQCKSDNE NYCPHLVDTY
GAPYPKEVDP DETISQGGYS SHIRAHEYFV FPIPDAIPSH LAAPMLCAGL TTWSPLVRAG
VGPGKKVAVV GLGGLGHFAV MWANALGAEV TVISHSPNKK EDALKLGAKE FVTNTEKGWA
DKYAFTFDFV INTADMTHTF DLQEYLSLCK VNATFHQVGL PDEALPPLKA QMFMSNGSSI
GASHIGNRPE ALAMLKLAAE KQLFPMVETL PISEKGCAEA VSRVAANKMR YRFTLTDYDK
AFGARD
//
