ID A0A0D2FXS3_9EURO Unreviewed; 799 AA.
AC A0A0D2FXS3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DUF221 domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z518_05064 {ECO:0000313|EMBL:KIX07087.1};
OS Rhinocladiella mackenziei CBS 650.93.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Rhinocladiella.
OX NCBI_TaxID=1442369 {ECO:0000313|EMBL:KIX07087.1, ECO:0000313|Proteomes:UP000053617};
RN [1] {ECO:0000313|EMBL:KIX07087.1, ECO:0000313|Proteomes:UP000053617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 650.93 {ECO:0000313|EMBL:KIX07087.1,
RC ECO:0000313|Proteomes:UP000053617};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Rhinocladiella mackenzie CBS 650.93.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KN847477; KIX07087.1; -; Genomic_DNA.
DR RefSeq; XP_013274223.1; XM_013418769.1.
DR AlphaFoldDB; A0A0D2FXS3; -.
DR GeneID; 25293135; -.
DR VEuPathDB; FungiDB:Z518_05064; -.
DR HOGENOM; CLU_002458_0_0_1; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000053617; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053617};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 23..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 682..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..191
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 211..411
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 422..700
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 799 AA; 91545 MW; BB0879EFEC2F5030 CRC64;
MSLNVFKNVN WGDQFKSSNQ RDFTTQVIIS VAFGLGAFLS FCVLRPKWTS LYHARKKQSG
AASRLPDLPK TLFGWIPVLY RISQEEVLAS AGLDAYAFLS FFRYAIKYLS VTLFFSLTII
LPVNYQFTGQ PPLMVPPRNG TDPDHGRDAF FSDGSKKPKK PAIEKDDSYL WMYVVFVYFF
TSVAIYLLIQ ETTNIIRVRQ AYLGTQSSIT DRTLRLSGIP KEMRSEEAIK NFIEDLQIGK
VDRVMLCRNW RALDNMMSTR MACLRKLEES WAVYLGHHHS FRHSRARRRR HDLLGDGDEE
ENGALLSRSE MEQAHVTPAD RPRPTITLRY GFLRIYSKKI DAIDYYEEKL KILDERIRVL
RESEFTPTPL AFVTMESTAA CQMAVQAILD PKPGQLLASL APPPADVVWK NTYLSRNHRM
IRSWSIMIFI GLLTVFWAAA LAPLAGLLSI EVIDKVLPGL AEALERHEIV RSLVQTGLPT
LLFSLLALAV PYLYDWLANQ QGMTSQGDVE LSVISKNFFF TFFNLFIVFT IWGSASTFYE
FWQGLRDILR DTAGIAYAIA KALEQLSPFY VNLIVLQGFG LFPFRLLEFG SMVLYPFYLI
RAKTPRDYAE LAKPPIFSYG FYLPQTMLIF IICIVYSVLP SSWMITLFGL IYFLIGGFIY
KYQLLYAMEH RQHSTGRAWP MICDRIVTGL ILFQVAMTGI LALRGALTAS LFLSPLLPAT
IWFTVYFHRT YVPLMRFIAL RSIDRNYFSD IPTPPESAWD RQTVDTDPDT GLCYINPNLV
CPLETLWIGK LDHRHRQPA
//
